Carrier proteins articles within Nature

Featured

• Article | 15 May 2024

  Dimerization and antidepressant recognition at noradrenaline transporter

  Cryo-electron microscopy structures of the noradrenaline transporter in the apo state, bound to noradrenaline and bound to various antidepressants shed light on the substrate transport, molecular recognition and dimeric architecture of this protein.

  • Heng Zhang
  • , Yu-Ling Yin
  •  & Yi Jiang

• Article | 18 March 2024

  Structural insights into vesicular monoamine storage and drug interactions

  Monoamines and neurotoxicants share a binding pocket in VMAT1 featuring polar sites for specificity and a wrist-and-fist shape for versatility, and monoamine enrichment in storage vesicles arises from dominant import via favoured lumenal-open transition of VMAT1 and protonation-precluded binding during its cytoplasmic-open transition.

  • Jin Ye
  • , Huaping Chen
  •  & Weikai Li

• Letter | 24 July 2011

  Mitochondrial uncoupling protein 2 structure determined by NMR molecular fragment searching

  • Marcelo J. Berardi
  • , William M. Shih
  •  & James J. Chou

• Letter | 20 March 2011

  Structure and mechanism of the uracil transporter UraA

  • Feiran Lu
  • , Shuo Li
  •  & Nieng Yan

• News & Views | 22 September 2010

  The coherent Mediator

  Enhancer sequences increase gene transcription with the help of a co-activator complex, the Mediator. Another protein complex — cohesin — seems to work with Mediator to bring together enhancers and promoters. See Article p. 430

  • Rolf Ohlsson