Featured
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Letter |
HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle
The deacetylase enzyme HDAC8 is identified as a crucial regulator of cohesin in humans, and loss-of-function mutations in the HDAC8 gene are found in patients with Cornelia de Lange syndrome.
- Matthew A. Deardorff
- , Masashige Bando
- & Katsuhiko Shirahige
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Letter |
Control of Drosophila endocycles by E2F and CRL4CDT2
- Norman Zielke
- , Kerry J. Kim
- & Bruce A. Edgar
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Letter |
A role for cohesin in T-cell-receptor rearrangement and thymocyte differentiation
- Vlad C. Seitan
- , Bingtao Hao
- & Matthias Merkenschlager
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News & Views |
Cyclin D1 multitasks
Cyclin D1 is one of the drivers of the cell cycle, and its deregulation may promote the development of tumours. Surprisingly, this protein also mediates the repair of damaged DNA, a mechanism that commonly prevents cancer. See Letter p.230
- Jiri Bartek
- & Jiri Lukas
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Letter |
A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers
- Siwanon Jirawatnotai
- , Yiduo Hu
- & Piotr Sicinski
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Article |
Driving the cell cycle with a minimal CDK control network
To investigate the core engine of the eukaryotic mitotic cycle, a minimal control network has been generated in fission yeast that efficiently sustains cellular reproduction. Orderly progression through the major events of the cell cycle is driven by oscillation of an engineered minimal CDK module lacking much of the canonical regulation.
- Damien Coudreuse
- & Paul Nurse
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Letter |
PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression
These authors show that the JmjC domain-containing protein PHF8 has histone demethylase activity against H4K20me1 and is linked to two distinct events during cell cycle progression. PHF8 is recruited to the promoters of genes involved in the G1–S phase transition, where it removes H4K20me1 and contributes to gene activation, whereas dissociation of PHF8 from chromatin in prophase allows H4K20me1 to accumulate during mitosis.
- Wen Liu
- , Bogdan Tanasa
- & Michael G. Rosenfeld
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Letter |
Transcriptional role of cyclin D1 in development revealed by a genetic–proteomic screen
Although cyclin D1 is frequently overexpressed in human cancers, the full range of its functions in normal development and oncogenesis is unclear. Here, tagged cyclin D1 knock-in mouse strains are developed to allow a search for cyclin D1-binding proteins in different mouse organs using high-throughput mass spectrometry. The results show that, in addition to its established cell cycle roles, cyclin D1 has an in vivo transcriptional function in mouse development.
- Frédéric Bienvenu
- , Siwanon Jirawatnotai
- & Piotr Sicinski
Post-replicative repair involves separase-dependent removal of the kleisin subunit of cohesin