Cell fate and cell lineage articles within Nature

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  • Article
    | Open Access

    A stream of young neurons migrating into the entorhinal cortex (EC) continues postnatally in humans, but not in macaques; these young neurons, which belong to a unique class of local circuit cells, continue to be recruited in the EC during infancy and early childhood.

    • Marcos Assis Nascimento
    • , Sean Biagiotti
    •  & Shawn F. Sorrells

  • Article |

    Analysis of cis-regulatory chromatin interactions, open chromatin and transcriptomes for different cell types isolated from mid-gestational human cortex samples provides insights into gene regulation during development.

    • Michael Song
    • , Mark-Phillip Pebworth
    •  & Yin Shen

  • Article |

    Single-cell RNA sequencing is used to catalogue and explore the developmental trajectories of more than 30,000 cells in the developing human hippocampus.

    • Suijuan Zhong
    • , Wenyu Ding
    •  & Xiaoqun Wang

  • Article |

    In the brains of embryonic mice, some types of progenitor (apical progenitors) can revert to earlier molecular, electrophysiological and neurogenic states when transplanted into younger hosts, whereas others cannot, highlighting progenitor-type-specific differences in fate plasticity.

    • Polina Oberst
    • , Sabine Fièvre
    •  & Denis Jabaudon

  • Article |

    A screen in which combinatorial pairs of transcription factors are exogenously expressed in fibroblasts identifies different combinations that reprogram these cells into induced neuronal cells with diverse functional properties.

    • Rachel Tsunemoto
    • , Sohyon Lee
    •  & Kristin K. Baldwin

  • Letter |

    Live imaging and single-cell analyses are used to show that decision-making by differentiating haematopoietic stem cells between the megakaryocytic–erythroid and granulocytic–monocytic lineages is not initiated by stochastic switching between the lineage-specific transcription factors PU.1 and GATA1, which challenges the previous model of early myeloid lineage choice.

    • Philipp S. Hoppe
    • , Michael Schwarzfischer
    •  & Timm Schroeder

  • Letter |

    Butterflies diversify their retinal mosaics by producing three stochastic types of ommatidia instead of the two types found in Drosophila; this study shows that butterfly retinas use two R7-like photoreceptors per ommatidium that each make an independent stochastic decision to express the transcription factor Spineless, which controls photoreceptor and ommatidial fate.

    • Michael Perry
    • , Michiyo Kinoshita
    •  & Claude Desplan

  • Article |

    Mouse and human fibroblasts can be reprogrammed to a pluripotent state with a combination of four transcription factors. Here, mature differentiated cells are directed, via a combination of a few transcription factors (distinct from those described for generating iPS cells), to form functional neurons in vitro, without having to revert the fibroblasts to an embryonic state.

    • Thomas Vierbuchen
    • , Austin Ostermeier
    •  & Marius Wernig

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