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Injury prevents Ras mutant cell expansion in mosaic skin
Following skin injury, wild-type epithelial cells outcompete oncogenic Ras G12V mutant cells owing to differential activation of the EGFR signalling pathway during injury repair.
- Sara Gallini
- , Karl Annusver
- & Valentina Greco
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Article
| Open Access
A time-resolved, multi-symbol molecular recorder via sequential genome editing
A DNA memory device, DNA Typewriter, uses sequential prime editing to record the order of multiple cellular events.
- Junhong Choi
- , Wei Chen
- & Jay Shendure
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Article |
Skin cells undergo asynthetic fission to expand body surfaces in zebrafish
Terminally differentiated superficial epithelial cells continue dividing in the absence of DNA replication to quickly expand epithelial coverage during rapid growth.
- Keat Ying Chan
- , Ching-Cher Sanders Yan
- & Chen-Hui Chen
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Article |
Fitness trade-offs incurred by ovary-to-gut steroid signalling in Drosophila
High levels of the sexually dimorphic hormone ecdysone, produced by active ovaries in Drosophila, promote the proliferation of stem cells in the female gut and maximize reproductive fitness, but also increase female susceptibility to age-dependent dysplasia and tumorigenesis.
- Sara Mahmoud H. Ahmed
- , Julieta A. Maldera
- & Bruce A. Edgar
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Letter |
Dystrophin–glycoprotein complex sequesters Yap to inhibit cardiomyocyte proliferation
After injury in the heart, postnatal mouse hearts deficient in the Hippo pathway show efficient repair, and in the hearts of Mdx mice (a model of Duchenne muscular dystrophy) Hippo deficiency protects against overload-induced heart failure.
- Yuka Morikawa
- , Todd Heallen
- & James F. Martin
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Letter |
Transmission of cytokinesis forces via E-cadherin dilution and actomyosin flows
Under physiological forces, resulting from cytokinesis, the mechanosensitivity of adherens junction arises from a local decrease in E-cadherin concentration and results in actomyosin flows.
- Diana Pinheiro
- , Edouard Hannezo
- & Yohanns Bellaïche
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Letter |
Synthetic recording and in situ readout of lineage information in single cells
A new system, termed MEMOIR, allows cells to record lineage and gene expression history within their own genome in a format that can be read out in single cells in situ.
- Kirsten L. Frieda
- , James M. Linton
- & Long Cai
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Letter |
FGF8 and SHH substitute for anterior–posterior tissue interactions to induce limb regeneration
The long-standing puzzle of why salamander limb regeneration requires anterior and posterior tissue interaction has been solved by the demonstration that fibroblast growth factor 8 and sonic hedgehog are key anterior and posterior cross-inductive signals that drive regeneration.
- Eugeniu Nacu
- , Elena Gromberg
- & Elly M. Tanaka
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Letter |
MARCKS-like protein is an initiating molecule in axolotl appendage regeneration
The salamander, or axolotl, is well known to be able to regenerate missing body parts, but the signals that drive the initial proliferative response were unclear; now, a secreted protein has been identified that induces the initial cell cycle response after injury.
- Takuji Sugiura
- , Heng Wang
- & Elly M. Tanaka
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Letter |
The sexual identity of adult intestinal stem cells controls organ size and plasticity
Reversible, cell-intrinsic mechanisms that depend on a new sex differentiation pathway act in adult somatic cells of the Drosophila intestine to govern sex-specific differences in organ size, plasticity during reproduction, and response to tumorigenic insults.
- Bruno Hudry
- , Sanjay Khadayate
- & Irene Miguel-Aliaga
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Article |
Dpp spreading is required for medial but not for lateral wing disc growth
The morphogen Decapentaplegic (Dpp) has been implicated in both wing patterning and growth in fruitflies; here, a nanobody-based morphotrap approach has been developed that rules out a role for the Dpp gradient in regulating lateral wing growth.
- Stefan Harmansa
- , Fisun Hamaratoglu
- & Emmanuel Caussinus
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Letter |
Decapentaplegic and growth control in the developing Drosophila wing
The morphogen Decapentaplegic (Dpp) has been implicated in both wing patterning and growth in fruitflies; here, a CRISPR–Cas9 approach is used to rule out the Dpp gradient driving wing growth.
- Takuya Akiyama
- & Matthew C. Gibson
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Article |
RNAi screens in mice identify physiological regulators of oncogenic growth
Here, the first genome-wide in vivo RNA interference screens in a mammalian animal model are reported: genes involved in normal and abnormal epithelial cell growth are studied in developing skin tissue in mouse embryos, and among the findings, β-catenin is shown to act as an antagonist to normal epithelial cell growth as well as promoting oncogene-driven growth.
- Slobodan Beronja
- , Peter Janki
- & Elaine Fuchs
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Letter |
Epithelial junctions maintain tissue architecture by directing planar spindle orientation
The Drosophila tumour suppressors Scribbled and Discs large 1 are found to be essential regulators of planar spindle alignment during epithelial cell division; aberrant effects of spindle alignment are shown to be corrected through apoptosis, and the suppression of this mechanism can result in epithelial dysplasia and tumorigenesis.
- Yu-ichiro Nakajima
- , Emily J. Meyer
- & Matthew C. Gibson
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News & Views |
Dormant and restless skin stem cells
It has been unclear whether a uniform group of stem cells gives rise to most cells in the epidermis. A study reveals the presence of at least two stem-cell populations that have different proliferative abilities. See Article p.257
- Laura De Rosa
- & Michele De Luca
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Article |
Distinct contribution of stem and progenitor cells to epidermal maintenance
Whether a single group of stem cells or multiple populations contribute to the homeostasis of the interfollicular epidermis is controversial; here the authors use lineage tracing and mathematical modelling to show that the progenitors that maintain mouse epidermis are underpinned by slow-cycling stem cells that become mobilized on injury.
- Guilhem Mascré
- , Sophie Dekoninck
- & Cédric Blanpain
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Research Highlights |
A mammalian change of heart
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News |
Young mammal hearts heal themselves
Organs in baby mice can recover from damage that occurs in the first week of life.
- Janelle Weaver
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Research Highlights |
Cell biology: Thriving with genomic errors
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Research Highlights |
Cancer: Melanoma's moving target
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Research Highlights |
Cancer biology: Arsenic activation
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Letter |
Targeted deletion of the 9p21 non-coding coronary artery disease risk interval in mice
Sequence variations in a 58-kilobase interval on human chromosome 9p21 have been associated with an increased risk of coronary artery disease. However, this interval contains no protein-coding genes and the mechanism underlying the increased risk has been unclear. Here, the corresponding interval has been deleted from mouse chromosome 4, revealing that this part of the chromosome regulates the cardiac expression of two nearby genes, Cdkn2a and Cdkn2b, and the proliferation dynamics of vascular cells.
- Axel Visel
- , Yiwen Zhu
- & Len A. Pennacchio
SHR and SCR coordinate root patterning and growth early in the cell cycle