Cerebellum articles within Nature

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  • Article |

    Mapping of the mouse cerebellar cortex using 3D reconstruction from electron microscopy, as well as numerical simulation of neuronal activity, shows non-random redundancy of connectivity that may favour resilient learning over encoding capacity.

    • Tri M. Nguyen
    • , Logan A. Thomas
    •  & Wei-Chung Allen Lee

  • Letter |

    Recording from Purkinje cells in monkeys, this study found that the combined simple-spike responses of bursting and pausing Purkinje cells, but not either population alone, predicted the real-time speed of saccades; moreover, when Purkinje cells were organized according to their complex-spike field, the population responses encoded both speed and direction of the eye during saccades via a gain field.

    • David J. Herzfeld
    • , Yoshiko Kojima
    •  & Reza Shadmehr

  • Letter |

    Recordings from monkeys during motor learning suggest that durations of complex-spike (CS) responses to climbing-fibre inputs are meaningful signals correlated across the Purkinje-cell population during motor learning; longer climbing-fibre bursts lead to longer-duration CS responses, larger synaptic depression and stronger learning, thus forming a graded instruction.

    • Yan Yang
    •  & Stephen G. Lisberger

  • Article |

    Cervical propriospinal neurons (PNs) form a genetically accessible subclass of V2a interneurons that convey both premotor output and precerebellar copy signals; their ablation in mice impairs reaching movements selectively, and activation of their internal copy projection recruits a rapid cerebellar feedback loop that modulates forelimb movement.

    • Eiman Azim
    • , Juan Jiang
    •  & Thomas M. Jessell

  • News & Views Forum |

    Purkinje cells in the brain region known as the cerebellum act by inhibiting their target neurons. A paper in this issue provides an explanation for how this inhibition might be used to control the timing of action potentials. But experts are not equally convinced about the functional relevance of this finding. See Letter p.502

    • Javier F. Medina
    •  & Kamran Khodakhah

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