Featured
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Affinity-coupled CCL22 promotes positive selection in germinal centres
CCL22 promotes positive selection in germinal centres by highlighting affinity-enhanced B cells for helper T cells to sense and seek remotely.
- Bo Liu
- , Yihan Lin
- & Hai Qi
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Article |
Commensal-driven immune zonation of the liver promotes host defence
The authors show that zonation extends to hepatic immune cells and that this spatial patterning is mediated by microbiome sensing by liver sinusoidal endothelial cells, and provide evidence that immune zonation is required to protect the host from the dissemination of blood-borne pathogens.
- Anita Gola
- , Michael G. Dorrington
- & Ronald N. Germain
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Article |
Structural basis of CXC chemokine receptor 2 activation and signalling
Structures of the Gi-coupled CXC chemokine receptor 2 (CXCR2) in complex with CXCL8 and in complex with an allosteric antagonist provide insight into the ligand binding and activation of CXCR2 and its mode of G-protein coupling.
- Kaiwen Liu
- , Lijie Wu
- & Zhi-Jie Liu
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Article |
A GPR174–CCL21 module imparts sexual dimorphism to humoral immunity
Male and female B cells show differing abilities to localize and contribute to germinal centres, in a way that depends on the G-protein-coupled guidance receptor GPR174 and its chemokine ligand CCL21.
- Ruozhu Zhao
- , Xin Chen
- & Hai Qi
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Letter |
S-Geranylgeranyl-l-glutathione is a ligand for human B cell-confinement receptor P2RY8
S-geranylgeranyl-l-glutathione (GGG) is identified as a cell signalling molecule that interacts with the receptor P2RY8 to mediate migration inhibition and growth regulation of germinal-centre B cells.
- Erick Lu
- , Finn D. Wolfreys
- & Jason G. Cyster
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Letter |
Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells
The chemoattractant S1P is identified as an extrinsic factor that supports naive T cell survival, and acts via a signalling mechanism to maintain mitochondrial content and function.
- Alejandra Mendoza
- , Victoria Fang
- & Susan R. Schwab
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Letter |
Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists
The crystal structure of CCR2 chemokine receptor in a complex with two different antagonists—one orthosteric the other allosteric—which functionally cooperate to inhibit CCR2.
- Yi Zheng
- , Ling Qin
- & Tracy M. Handel
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Article |
Ribosomal frameshifting in the CCR5 mRNA is regulated by miRNAs and the NMD pathway
Programmed −1 ribosomal frameshifting (−1 PRF) is a process by which a signal in a messenger RNA causes a translating ribosome to shift by one nucleotide, thus changing the reading frame; here −1 PRF in the mRNA for the co-receptor for HIV-1, CCR5, is stimulated by two microRNAs and leads to degradation of the transcript by nonsense-mediated decay and at least one other decay pathway.
- Ashton Trey Belew
- , Arturas Meskauskas
- & Jonathan D. Dinman
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Letter |
Generalized Lévy walks and the role of chemokines in migration of effector CD8+ T cells
T cells in the brains of Toxoplasma-infected mice are shown to move by Lévy-like walks.
- Tajie H. Harris
- , Edward J. Banigan
- & Christopher A. Hunter
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Letter |
Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein
A family of small molecules called ‘ciliobrevins’ are described that can rapidly and reversibly modulate the AAA+ ATPase motor dynein, which transports cargo molecules along microtubule tracks.
- Ari J. Firestone
- , Joshua S. Weinger
- & James K. Chen
Monocyte-derived S1P in the lymph node regulates immune responses