Featured
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Article |
Sodium regulates clock time and output via an excitatory GABAergic pathway
The authors demonstrate that clock time can be regulated by non-photic physiologically relevant cues and that such cues can drive unscheduled homeostatic responses via clock-output networks.
- Claire Gizowski
- & Charles W. Bourque
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Letter |
Circadian clock neurons constantly monitor environmental temperature to set sleep timing
The DN1p clock neurons of Drosophila melanogaster continuously report temperature changes into the circadian neural network, to control the timing of sleep and activity.
- Swathi Yadlapalli
- , Chang Jiang
- & Orie T. Shafer
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Letter |
A rhodopsin in the brain functions in circadian photoentrainment in Drosophila
The Drosophila rhodopsin Rh7 works with cryptochrome to mediate circadian light entrainment by pacemaker neurons.
- Jinfei D. Ni
- , Lisa S. Baik
- & Craig Montell
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Letter |
Clock-driven vasopressin neurotransmission mediates anticipatory thirst prior to sleep
Clock neurons projecting from the suprachiasmatic nucleus activate a thirst-related brain area in mice to cause a surge in drinking just before sleep and thereby to prevent dehydration during the sleep period.
- C. Gizowski
- , C. Zaelzer
- & C. W. Bourque
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Letter |
Drosophila Ionotropic Receptor 25a mediates circadian clock resetting by temperature
A Drosophila chemosensory receptor, expressed in leg sensory neurons, is necessary for behavioural and molecular synchronization of the fly’s circadian clock to low-amplitude temperature cycles; this temperature-sensing pathway functions independently from the known temperature sensors of the fly’s antennae.
- Chenghao Chen
- , Edgar Buhl
- & Ralf Stanewsky
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Letter |
Unexpected features of Drosophila circadian behavioural rhythms under natural conditions
Behavioural, neurogenetic and molecular studies of circadian 24-hour rhythms in fruitflies kept in semi-confinement outdoors challenge our established laboratory-based views of the relative importance of sources of rhythmic entrainment, including temperature, photoperiod and moonlight, as well as the role of some of the underlying clock genes in regulating circadian behaviour in the wild.
- Stefano Vanin
- , Supriya Bhutani
- & Charalambos P. Kyriacou
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News & Views |
On time metabolism
In mammals, molecular clocks regulate transcription and glucose homeostasis. One way they do so is by controlling glucocorticoid-receptor signalling, which suggests that clocks are embedded in liver metabolism. See Letter p.552
- Joseph Bass
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Letter |
Cryptochromes mediate rhythmic repression of the glucocorticoid receptor
Circadian co-regulators cryptochrome 1 and 2 are shown to alter globally the transcriptional response to glucocorticoids in mouse embryonic fibroblasts.
- Katja A. Lamia
- , Stephanie J. Papp
- & Ronald M. Evans
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Research Highlights |
Biological clocks work in the dark
Cryptochrome–Timeless structure reveals circadian clock timing mechanisms
Structure: The anatomy of sleep