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FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation
FAM72A differentially controls mutation rates by regulating uracil processing at different stages of the cell cycle, thereby regulating somatic hypermutation and class-switch recombination in B cells.
- Yuqing Feng
- , Conglei Li
- & Alberto Martin
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Article |
Structural basis of malaria RIFIN binding by LILRB1-containing antibodies
Plasmodium antigens called RIFINs bind to specific antibodies that incorporate the inhibitory receptor LILRB1 through its D3 domain, illustrating the principle of receptor-containing antibodies.
- Yiwei Chen
- , Kai Xu
- & Antonio Lanzavecchia
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Article |
Fundamental roles of chromatin loop extrusion in antibody class switching
Chromatin loop extrusion has fundamental mechanistic roles in immunoglobulin heavy chain class switch recombination.
- Xuefei Zhang
- , Yu Zhang
- & Frederick W. Alt
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Letter |
Analysis of the B cell receptor repertoire in six immune-mediated diseases
An analysis of the B cell receptor repertoire in six immune-mediated diseases reveals that there are substantial differences in clonality, isotype use, class switching and use of the IGHV genes between diseases.
- R. J. M. Bashford-Rogers
- , L. Bergamaschi
- & K. G. C. Smith
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Letter |
Germinal centre hypoxia and regulation of antibody qualities by a hypoxia response system
Hypoxia in germinal centres regulates B cell class switching via its effects on mTOR complex 1 and activation-induced cytosine deaminase activity.
- Sung Hoon Cho
- , Ariel L. Raybuck
- & Mark R. Boothby
Fam72a enforces error-prone DNA repair during antibody diversification