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Open Access
Featured
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Antibiotic combinations reduce Staphylococcus aureus clearance
Different pairs of antibiotics show qualitatively different bacterial clearance interactions—some pairs show reciprocal suppression whereby the drug mixture efficacy is weaker than the individual drugs alone, and the clearance efficacy decreases as more drugs are added.
- Viktória Lázár
- , Olga Snitser
- & Roy Kishony
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Article |
Statin therapy is associated with lower prevalence of gut microbiota dysbiosis
A cross-sectional analysis of participants in the MetaCardis Body Mass Index Spectrum cohort finds that the higher prevalence of gut microbiota dysbiosis in individuals with obesity is not observed in those who take statin drugs.
- Sara Vieira-Silva
- , Gwen Falony
- & Jeroen Raes
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Letter |
Stunted microbiota and opportunistic pathogen colonization in caesarean-section birth
Delivery via caesarean section, maternal antibiotic prophylaxis and colonization by opportunistic pathogens associated with the hospital environment affect the composition of the gut microbiota of children from birth until infancy.
- Yan Shao
- , Samuel C. Forster
- & Trevor D. Lawley
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Letter |
Methicillin-resistant Staphylococcus aureus alters cell wall glycosylation to evade immunity
Strains of methicillin-resistant Staphylococcus aureus use a prophage-encoded glycosyltransferase to alter the glycosylation of their wall teichoic acid and thereby evade antibody-mediated immune responses.
- David Gerlach
- , Yinglan Guo
- & Andreas Peschel
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Letter
| Open Access
Temporal development of the gut microbiome in early childhood from the TEDDY study
Metagenomic sequencing analysis of stool samples from 903 children as part of the TEDDY study shows that breastfeeding was the most important factor associated with microbiome structure, and the cessation of breast milk resulted in faster maturation of the gut microbiome.
- Christopher J. Stewart
- , Nadim J. Ajami
- & Joseph F. Petrosino
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Article |
Dietary trehalose enhances virulence of epidemic Clostridium difficile
Two hypervirulent ribotypes of the enteric pathogen Clostridium difficile, RT027 and RT078, have independently acquired unique mechanisms to metabolize low concentrations of the disaccharide trehalose, suggesting a correlation between the emergence of these ribotypes and the widespread adoption of trehalose in the human diet.
- J. Collins
- , C. Robinson
- & R. A. Britton
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News |
Bacterium offers way to control dengue fever
Wolbachia strain halts virus in mosquitoes.
- Natasha Gilbert
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News Feature |
Microbiology: The new germ theory
What can microbiologists who study human bowels learn from those who study the bowels of Earth?
- Lizzie Buchen
Genomic investigations of unexplained acute hepatitis in children