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Open Access
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Young CSF restores oligodendrogenesis and memory in aged mice via Fgf17
Fgf17 in young CSF boosts oligodendrocyte progenitor cell proliferation and differentiation in the aged hippocampus, improving memory function.
- Tal Iram
- , Fabian Kern
- & Tony Wyss-Coray
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Article |
Restoring metabolism of myeloid cells reverses cognitive decline in ageing
In aged mice, inhibition of prostaglandin E2 (PGE2) signalling through its receptor EP2 improves cellular bioenergetics, reduces inflammatory responses and restores hippocampal plasticity to youthful levels, resulting in an improvement in spatial memory and cognition.
- Paras S. Minhas
- , Amira Latif-Hernandez
- & Katrin I. Andreasson
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Article |
Single-cell analysis reveals T cell infiltration in old neurogenic niches
Single-cell transcriptomic analysis of neurogenic niches in young and old mice reveals that T cells infiltrate the neurogenic niches of old mice and inhibit the proliferation of neural stem cells, in part through expression of interferon-γ.
- Ben W. Dulken
- , Matthew T. Buckley
- & Anne Brunet
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Letter |
A shared neural ensemble links distinct contextual memories encoded close in time
A similar neural ensemble participates in the encoding of two distinct memories, resulting in the recall of one memory increasing the likelihood of recalling the other, but only if those memories occur very closely in time—within a day rather than across a week.
- Denise J. Cai
- , Daniel Aharoni
- & Alcino J. Silva
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Letter |
Video game training enhances cognitive control in older adults
Training with a multitasking video game is shown to improve cognitive control abilities that decline with age, revealing the plasticity of the ageing brain; these behavioural improvements were accompanied by underlying neural changes that predicted the training-induced boost in sustained attention and enhanced multitasking performance 6 months later.
- J. A. Anguera
- , J. Boccanfuso
- & A. Gazzaley
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News |
Life-long intelligence in the genes
Study tracks cognitive stability from childhood to old age and reveals extent of genetic influence.
- Heidi Ledford
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Letter |
Genetic contributions to stability and change in intelligence from childhood to old age
Using a unique and rich data set of lifetime cognitive measures, the contribution of genetics to differences in cognitive ageing is explored.
- Ian J. Deary
- , Jian Yang
- & Peter M. Visscher
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Research Highlights |
How the brain slows with age
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Research Highlights |
Neuroscience: Ageing on the brain
Platelet factors attenuate inflammation and rescue cognition in ageing