Cortex articles within Nature

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  • Article |

    Offline cortical reactivations predict the gradual drift and separation in sensory cortical response patterns and may enhance sensory discrimination.

    • Nghia D. Nguyen
    • , Andrew Lutas
    •  & Mark L. Andermann

  • Article
    | Open Access

    Rule-shift behavioural experiments in mice demonstrate that callosal projections of parvalbumin-expressing neurons switch prefrontal circuits from maintenance mode to rule-learning mode by gating inputs from other callosal inputs that maintain previous rule representations.

    • Kathleen K. A. Cho
    • , Jingcheng Shi
    •  & Vikaas S. Sohal

  • Article
    | Open Access

    A study using calcium imaging in the mouse forepaw system identifies neurons in the posterior insular cortex that respond to cooling and/or warming with distinct response dynamics.

    • M. Vestergaard
    • , M. Carta
    •  & J. F. A. Poulet

  • Article |

    Behavioural studies with deafened rats show that locus coeruleus activity and plasticity are key to rapid adaptation to and long-term hearing performance with cochlear implants.

    • Erin Glennon
    • , Silvana Valtcheva
    •  & Robert C. Froemke

  • Article |

    Genetic manipulation of skin peripheral sensory neurons in mice shows that cortical neuron responses to touch reflect subcortical mixing of signals from both rapidly adapting and slowly adapting low-threshold mechanoreceptors.

    • Alan J. Emanuel
    • , Brendan P. Lehnert
    •  & David D. Ginty

  • Article |

    Cell-type-specific electrophysiological recording, fibre photometry and optogenetic manipulations in mice show that dopamine signals from the ventral tegmental area to the lateral entorhinal cortex have a key role in cue–reward associative learning.

    • Jason Y. Lee
    • , Heechul Jun
    •  & Kei M. Igarashi

  • Article |

    All odours elicit a unique pattern of neuronal activity in primary olfactory cortex but these patterns drift over time, posing a problem for the perceptual constancy of odours.

    • Carl E. Schoonover
    • , Sarah N. Ohashi
    •  & Andrew J. P. Fink

  • Letter |

    Cells in the mouse medial entorhinal cortex that fire when mice are at a specific distance and direction from a stationary object suggest that vector coding is important for rodent navigation.

    • Øyvind Arne Høydal
    • , Emilie Ranheim Skytøen
    •  & Edvard I. Moser

  • Letter |

    Training of mice to associate a particular sound frequency with locomotion results in selective suppression of cortical responses to that frequency during movement, consistent with a motor-dependent form of auditory cortical plasticity.

    • David M. Schneider
    • , Janani Sundararajan
    •  & Richard Mooney

  • Article |

    Spatial working memory is known to involve the prefrontal cortex and the hippocampus, but the specificities of the connection have been unclear; now, a direct path between these two areas is defined that is necessary for the encoding of spatial cues in mice, but is not required for the maintenance or retrieval of these cues.

    • Timothy Spellman
    • , Mattia Rigotti
    •  & Joshua A. Gordon

  • Article |

    A study of pup retrieval behaviour in mice shows that oxytocin modulates cortical responses to pup calls specifically in the left auditory cortex; in virgin females, call-evoked responses were enhanced, thus increasing their salience, by pairing oxytocin delivery in the left auditory cortex with the calls, suggesting enhancement was a result of balancing the magnitude and timing of inhibition with excitation.

    • Bianca J. Marlin
    • , Mariela Mitre
    •  & Robert C. Froemke

  • Article |

    Ca2+ spikes are generated on different dendritic branches in the primary motor cortex of mice performing different motor learning tasks, causing long-lasting potentiation of postsynaptic dendritic spines; inactivation of a population of interneurons disrupts the spatial separation of Ca2+ spikes and persistent dendritic spine potentiation, suggesting that the generation of Ca2+ spikes on different dendritic branches is crucial for storing information in individual neurons.

    • Joseph Cichon
    •  & Wen-Biao Gan

  • Article |

    Here auditory cortex excitatory neurons are shown to decrease their activity during locomotion, grooming and vocalization, and this decrease was paralleled by increased activity in inhibitory interneurons; these findings provide a circuit basis for how self-motion and external sensory signals can be integrated to potentially facilitate hearing.

    • David M. Schneider
    • , Anders Nelson
    •  & Richard Mooney

  • Letter |

    During learning, the new patterns of neural population activity that develop are constrained by the existing network structure so that certain patterns can be generated more readily than others.

    • Patrick T. Sadtler
    • , Kristin M. Quick
    •  & Aaron P. Batista

  • Letter |

    Inhibitory neuron activity is found to be relatively stable during motor learning whereas excitatory neuron activity is much more dynamic — the results indicate that a large number of neurons exhibit activity changes early on during motor learning, but this population is refined with subsequent practice.

    • Andrew J. Peters
    • , Simon X. Chen
    •  & Takaki Komiyama

  • Letter |

    Cortical inhibitory interneurons expressing vasoactive intestinal polypeptide (VIP) are shown to specialize in suppressing the activity of other inhibitory interneurons and are activated by reinforcement signals, thus increasing the activity of excitatory neurons by releasing them from inhibition; these results reveal a cell-type-specific microcircuit that tunes cortical activity under certain behavioural conditions.

    • Hyun-Jae Pi
    • , Balázs Hangya
    •  & Adam Kepecs

  • Letter |

    In an auditory frequency discrimination task in rats, channelrhodopsin-2-mediated stimulation of corticostriatal neurons biases decisions in the direction predicted by the frequency tuning of the stimulated neurons, whereas archaerhodopsin-3-mediated inactivation biases decisions in the opposite direction.

    • Petr Znamenskiy
    •  & Anthony M. Zador

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