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Sensory-evoked LTP driven by dendritic plateau potentials in vivo
Whole-cell recordings in mouse somatosensory cortex in vivo show that rhythmic sensory-whisker stimulation induces long-term synaptic potentiation (LTP) in layer 2/3 (L2/3) pyramidal cells, in the absence of somatic spikes, through long-lasting NMDAR-mediated depolarizations that are generated by synaptic networks originating from the posteromedial complex of the thalamus.
- Frédéric Gambino
- , Stéphane Pagès
- & Anthony Holtmaat