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Dengue virus is an infectious agent that causes the tropical disease dengue fever in humans. This virus species is transmitted by mosquitoes (arthropods) and thus is an arbovirus.
Dengue is a major public health concern in the Americas, and the Caribbean can be a source for reintroduction and spread. Here, the authors use travel surveillance data and genomic epidemiology to reconstruct Dengue epidemic dynamics in the Caribbean from 2009-2022.
Hanley et al show that transmission of dengue and Zika virus from Old and New World monkeys is shaped by an immunologically-mediated trade-off between magnitude and duration of replication. Patterns of Zika transmission suggests high risk of spillback into neotropical monkeys.
In an analysis of severe dengue cases in a cohort of children in India, more than half could be attributed to primary rather than secondary infection, suggesting that primary dengue infections might also contribute substantially to severe disease burden.
There is still a need to improve understanding of dengue-specific immunity. Here, by analyzing the antibody response in a pediatric cohort the authors show that the protective capacity of neutralizing antibodies depends on infection history and serotype, but its estimation varies by assay condition and virion maturation.
In this study, Zhang et al. report that a bacterial symbiont residing in the gut of Aedes albopictus mosquitoes protects them from flavivirus infection.
This study suggests that pre-existing DENV immunity has a negative effect on the pathogenesis of secondary ZIKV infection during pregnancy in marmosets.
A new study shows that many olfactory sensory neurons in Aedes aegypti mosquitoes express more than one type of chemosensory receptor and some of these neurons can respond to multiple olfactory cues.