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Open Access
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Article
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Ultra-fast deep-learned CNS tumour classification during surgery
Sturgeon is a pretrained neural network that uses incremental results from nanopore sequencing to rapidly classify central nervous system tumours and can be used to aid critical decision-making during surgery.
- C. Vermeulen
- , M. Pagès-Gallego
- & J. de Ridder
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Perspective |
Practical recommendations for using ctDNA in clinical decision making
This Perspective reviews the utility and interpretation of circulating tumour DNA for the detection of residual and recurrent cancers and provides recommendations regarding its clinical application for a variety of solid tumours.
- Stacey A. Cohen
- , Minetta C. Liu
- & Alexey Aleshin
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Article
| Open Access
Swarm Learning for decentralized and confidential clinical machine learning
Swarm Learning is a decentralized machine learning approach that outperforms classifiers developed at individual sites for COVID-19 and other diseases while preserving confidentiality and privacy.
- Stefanie Warnat-Herresthal
- , Hartmut Schultze
- & Joachim L. Schultze
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Article |
ALDH4A1 is an atherosclerosis auto-antigen targeted by protective antibodies
An autoantibody found in a mouse model of atherosclerosis recognizses ALDH4A1, and infusion of the antibody delays plaque formation in mice.
- Cristina Lorenzo
- , Pilar Delgado
- & Almudena R. Ramiro
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Article |
Metallaphotoredox aryl and alkyl radiomethylation for PET ligand discovery
A versatile and rapid metallaphotoredox catalytic method of making 3H- and 11C-labelled tracer compounds for use in positron emission tomography (PET) is reported.
- Robert W. Pipal
- , Kenneth T. Stout
- & David W. C. MacMillan
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Matters Arising |
Transparency and reproducibility in artificial intelligence
- Benjamin Haibe-Kains
- , George Alexandru Adam
- & Hugo J. W. L. Aerts
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Article |
Hepatic NADH reductive stress underlies common variation in metabolic traits
The authors identify an increased hepatic NADH/NAD+ ratio as an underlying metabolic parameter that is shaped by human genetic variation and contributes causally to key metabolic traits and diseases.
- Russell P. Goodman
- , Andrew L. Markhard
- & Vamsi K. Mootha
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Article |
Microbiome analyses of blood and tissues suggest cancer
diagnostic approach
Microbial nucleic acids are detected in samples of tissues and blood from more than 10,000 patients with cancer, and machine learning is used to show that these can be used to discriminate between and among different types of cancer, suggesting a new microbiome-based diagnostic approach.
- Gregory D. Poore
- , Evguenia Kopylova
- & Rob Knight
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Article |
Discriminating α-synuclein strains in Parkinson’s disease and multiple system atrophy
Protein misfolding cyclic amplification (PMCA) technology can discriminate between patients with Parkinson’s disease and patients with multiple system atrophy on the basis of the characteristics of the α-synuclein aggregates in the cerebrospinal fluid.
- Mohammad Shahnawaz
- , Abhisek Mukherjee
- & Claudio Soto
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Letter |
Actively personalized vaccination trial for newly diagnosed glioblastoma
In a phase I trial, highly individualized peptide vaccines against unmutated tumour antigens and neoepitopes elicited sustained responses in CD8+ and CD4+ T cells, respectively, in patients with newly diagnosed glioblastoma.
- Norbert Hilf
- , Sabrina Kuttruff-Coqui
- & Wolfgang Wick
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Letter |
High performance plasma amyloid-β biomarkers for Alzheimer’s disease
Measurement of human plasma amyloid-β biomarkers using immunoprecipitation coupled with mass spectrometry reliably predicts individual brain amyloid-β status and has potential clinical utility.
- Akinori Nakamura
- , Naoki Kaneko
- & Katsuhiko Yanagisawa
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Article |
Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution
Circulating tumour DNA profiling in early-stage non-small-cell lung cancer can be used to track single-nucleotide variants in plasma to predict lung cancer relapse and identify tumour subclones involved in the metastatic process.
- Christopher Abbosh
- , Nicolai J. Birkbak
- & Charles Swanton
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Letter |
Transfer of mitochondria from astrocytes to neurons after stroke
In a mouse model of ischaemia, mitochondrial particles released from astroctyes are taken up by adjacent neurons, leading to enhanced cell survival signalling; disruption of this release mechanism resulted in worsened neurological outcomes.
- Kazuhide Hayakawa
- , Elga Esposito
- & Eng H. Lo
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Brief Communications Arising |
Decompensated cirrhosis and microbiome interpretation
- Jasmohan S. Bajaj
- , Naga S. Betrapally
- & Patrick M. Gillevet
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Article |
Glypican-1 identifies cancer exosomes and detects early pancreatic cancer
Glypican-1 identifies cancer exosomes and serves as a biomarker for detection of early pancreatic cancer in patients and mouse models of the disease; the findings may enable early and non-invasive identification, and prevention of malignant cancer.
- Sonia A. Melo
- , Linda B. Luecke
- & Raghu Kalluri
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News |
The TB test you can do at home
Latest fluorescent probe can detect tuberculosis bacteria using a homemade light box and a mobile-phone camera.
- Alyssa Joyce
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News |
Urine predicts prostate cancer risk
Test could reduce unnecessary needle biopsies.
- Virginia Gewin
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News |
Alzheimer's blood test 'most accurate' so far
The blood of patients with the brain disease contains antibodies not found in healthy people.
- Ewen Callaway
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Organ aging signatures in the plasma proteome track health and disease