Featured
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Article |
Quasi-experimental evaluation of a nationwide diabetes prevention programme
Analysis of the largest behaviour change programme for prediabetes globally provides causal evidence that lifestyle advice and counselling implemented at scale can improve key cardiovascular risk factors.
- Julia M. Lemp
- , Christian Bommer
- & Pascal Geldsetzer
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Article
| Open AccessThe burden and dynamics of hospital-acquired SARS-CoV-2 in England
Data from acute hospitals in England are used to quantify hospital-acquired SARS-CoV-2 infections, evaluate likely pathways of spread and factors associated with heightened transmission risk, and explore the impact on community transmission.
- Ben S. Cooper
- , Stephanie Evans
- & Gwenan M. Knight
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Article
| Open AccessA wearable cardiac ultrasound imager
Innovations in device design, material fabrication and deep learning are described, leading to a wearable ultrasound transducer capable of dynamic cardiac imaging in various environments and under different conditions.
- Hongjie Hu
- , Hao Huang
- & Sheng Xu
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Article
| Open AccessA synergistic mindsets intervention protects adolescents from stress
An online training module that synergistically targets two different mindsets can reduce stress levels in adolescents in the context of social-evaluative stressors—stressful experiences in which individuals fear that others are judging them negatively.
- David S. Yeager
- , Christopher J. Bryan
- & Jeremy P. Jamieson
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Article |
The power of genetic diversity in genome-wide association studies of lipids
A genome-wide association meta-analysis study of blood lipid levels in roughly 1.6 million individuals demonstrates the gain of power attained when diverse ancestries are included to improve fine-mapping and polygenic score generation, with gains in locus discovery related to sample size.
- Sarah E. Graham
- , Shoa L. Clarke
- & Cristen J. Willer
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Article |
BNT162b2 vaccine induces neutralizing antibodies and poly-specific T cells in humans
In a phase-I/II trial in healthy adults, the BNT162b2 vaccine induces neutralizing antibodies and poly-specific T cells against SARS-CoV-2 epitopes that are conserved in a wide range of currently circulating variants.
- Ugur Sahin
- , Alexander Muik
- & Özlem Türeci
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Article
| Open AccessMapping routine measles vaccination in low- and middle-income countries
Although progress in the coverage of routine measles vaccination in children in low- and middle-income countries was made during 2000–2019, many countries remain far from the goal of 80% coverage in all districts by 2019.
- Alyssa N. Sbarra
- , Sam Rolfe
- & Jonathan F. Mosser
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Article |
A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity
A recombinant vaccine that targets the receptor-binding domain of the spike protein of SARS-CoV-2 induces a potent antibody response in immunized mice, rabbits and non-human primates, and protects primates from infection with the virus.
- Jingyun Yang
- , Wei Wang
- & Xiawei Wei
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Article |
A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2
Two monoclonal antibodies isolated from a patient with COVID-19 are shown to interfere with SARS-CoV-2–receptor binding, and one displays potent action against this virus in vitro and in a rhesus macaque model.
- Rui Shi
- , Chao Shan
- & Jinghua Yan
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Article |
Effect of non-pharmaceutical interventions to contain COVID-19 in China
A model of the effects of different non-pharmaceutical interventions on the spread of COVID-19 in China suggests that a strategy involving the rapid implementation of a combination of interventions is most effective.
- Shengjie Lai
- , Nick W. Ruktanonchai
- & Andrew J. Tatem
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Article |
Population flow drives spatio-temporal distribution of COVID-19 in China
Modelling of population flows in China enables the forecasting of the distribution of confirmed cases of COVID-19 and the identification of areas at high risk of SARS-CoV-2 transmission at an early stage.
- Jayson S. Jia
- , Xin Lu
- & Nicholas A. Christakis
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Letter |
A clinically applicable approach to continuous prediction of future acute kidney injury
A deep learning approach that predicts the risk of acute kidney injury may help to identify patients at risk of health deterioration within a time window that enables early treatment.
- Nenad Tomašev
- , Xavier Glorot
- & Shakir Mohamed
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Outlook |
Public health: The politics of antibiotics
Policy-makers and medical experts need to think globally if we are to prevent an antibiotic 'tragedy of the commons'.
- Megan Cully
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Outlook |
Perspective: Obesity is not a disease
The misguided urge to pathologize this condition reflects society's failure to come to terms with the need for prevention, says D. L. Katz.
- D. L. Katz
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Outlook |
Treatment: Marginal gains
Behavioural interventions work, but not for everyone, and weight regain is common. Are there better ways to treat obesity?
- Emily Anthes
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News |
Hepatitis E vaccine debuts
Success of Chinese biotech partnership raises hopes for prevention of overlooked diseases.
- Soo Bin Park
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Outlook |
Nutrition: The vitamin D complex
Many COPD patients are deficient in vitamin D, a condition that can lead to bone problems as well as difficulty breathing. Can dietary supplements be of help?
- Thea Singer
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News |
Fish Oil Supplement Research Remains Murky
Polyunsaturated omega-3 fatty acids are important parts of a healthy diet, but supplement studies have numerous sampling problems
- Melinda Wenner Moyer
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Research Highlights |
A treatable form of autism
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News |
Amino-acid deficiency underlies rare form of autism
Genetic mutations in metabolic pathway could be fixed with nutritional supplement.
- Ewen Callaway
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Outlook |
Q&A: On the case
A Nobel prizewinner for pinning cervical cancer on human papillomavirus, Harald zur Hausen still investigates viruses. Nature Outlook talks to the medical doctor–turned–virologist about other possible culprits.
- Harald zur Hausen
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News |
Mapping identifies best targets for malaria prevention
Seasonal treatment would save lives, but leave many behind.
- Amy Maxmen
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Comment |
Bring safe sex to China
China's discomfort over discussing sex, and especially homosexuality, is a major problem when it comes to HIV, says a consortium of researchers in China.
- Hong Shang
- , Junjie Xu
- & Linqi Zhang
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Outlook |
Prevention: Nipped in the bud
While type 1 diabetes might be promising ground for a vaccine, the most effective way to avoid type 2 remains good old-fashioned diet and exercise.
- Scott P. Edwards
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Outlook |
Immunomodulators: Cell savers
In type 1 diabetes, the immune system goes haywire and depletes insulin-producing cells. Drugs that interfere with this process could one day reverse the disease's course.
- Sarah DeWeerdt
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News |
Malaria surge feared
The WHO releases action plan to tackle the spread of insecticide-resistant mosquitoes.
- Amy Maxmen
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Outlook |
The numbers game
Nature Outlook maps the challenges in tackling the malaria epidemic.
- Priya Shetty
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Outlook |
Vector control: The last bite
Preventing mosquitoes from transmitting the malaria parasite is a crucial piece of the eradication puzzle.
- Lauren Gravitz
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Outlook |
Cancer: Solving an age-old problem
Is cancer ancient, or is it largely a product of modern times? And can the latest research on prevention and treatment strategies make cancer a disease of the past?
- Barbara Dunn
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News |
US disease agency in fiscal peril
Proposed budget changes threaten disease prevention and surveillance programmes.
- Meredith Wadman
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News |
Can a vaccine cure Haiti's cholera?
Two years after the earthquake and thousands of deaths later, the debate about whether to use the cholera vaccine in Haiti continues.
- Katherine Harmon
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News |
India on track to be declared polio-free next month
The polio virus has disappeared from the country for 12 months, but it could still be re-imported from neighboring nations.
- Helen Branswell
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News |
Modified mosquitoes set to quash dengue fever
Wolbachia infection expected to halt virus transmission in Australian trial.
- David Cyranoski
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Outlook |
Lifestyle: When allergies go west
Modern living seems somehow to make our immune systems overly sensitive. Is cleanliness at fault — or something else?
- Duncan Graham-Rowe
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Research Highlights |
Sterile males for mosquito control
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News |
Friendly bacteria move in mysterious ways
Probiotic yoghurts have only a small effect on gut bacteria.
- Ed Yong
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Outlook |
Perspective: Prevention is better than cure
Attempts to reduce amyloid-β in the brain have yet to show clinical benefits. Starting treatment early is the best hope, says Sam Gandy
- Sam Gandy
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Outlook |
Prevention: Activity is the best medicine
Can exercise, social interaction and the Mediterranean diet really help to keep the cognitive decline of Alzheimer's disease at bay?
- Sarah DeWeerdt
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News Feature |
Nutrition advice: The vitamin D-lemma
A vociferous debate about vitamin-D supplementation reveals the difficulty of distilling strong advice from weak evidence.
- Amy Maxmen
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Editorial |
A big disease with a little name
Three decades on from the first published cases of what would later be recognized as AIDS, the social and cultural challenges of the disease remain.
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Comment |
Stigma impedes AIDS prevention
Medical advances cannot help those who deny they are at risk of HIV and avoid HIV tests. Salim S. Abdool Karim describes how such attitudes may be overcome.
- Salim S. Abdool Karim
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Letter |
Ultra-prolonged activation of CO2-sensing neurons disorients mosquitoes
- Stephanie Lynn Turner
- , Nan Li
- & Anandasankar Ray
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Comment |
Lessons from polio eradication
Ridding the world of polio requires a global initiative that tailors strategies to communities, say Heidi J. Larson and Isaac Ghinai.
- Heidi J. Larson
- & Isaac Ghinai
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Research Highlights |
Taming psoriasis with vitamin D
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News & Views |
The diet–microbe morbid union
A common dietary component that some people even take as a supplement is converted by the gut microbiota to harmful metabolites linked to heart disease. This finding has cautionary implications. See Article p.57
- Kimberly Rak
- & Daniel J. Rader
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Outlook |
Lifestyle: Breaking the cancer habit
It's the simple things in life that sometimes mean the most to people— and do the most good.
- Cassandra Willyard