Featured
-
-
Article |
HRG-9 homologues regulate haem trafficking from haem-enriched compartments
HRG-9 (also known as TANGO2) is an evolutionarily conserved haem chaperone that traffics haem from sites of storage or synthesis in eukaryotic cells.
- Fengxiu Sun
- , Zhenzhen Zhao
- & Caiyong Chen
-
Article
| Open AccessEnhanced fitness of SARS-CoV-2 variant of concern Alpha but not Beta
The Alpha variant of SARS-CoV-2 outcompetes progenitor SARS-CoV-2 in upper respiratory tract replication competition in vivo.
- Lorenz Ulrich
- , Nico Joel Halwe
- & Charaf Benarafa
-
Article |
Virus-induced senescence is a driver and therapeutic target in COVID-19
Virus-induced senescence is a central pathogenic feature in COVID-19, and senolytics, which promote apoptosis of senescent cells, can reduce disease severity in hamsters,mice, as well as humans infected with SARS-CoV-2.
- Soyoung Lee
- , Yong Yu
- & Clemens A. Schmitt
-
Article |
Evaluating microbiome-directed fibre snacks in gnotobiotic mice and humans
Fibre snacks that target distinct features of the microbiomes of donors with obesity transplanted into gnotobiotic mice also lead to fibre-specific changes in the microbiome and physiology when used in controlled-diet human studies.
- Omar Delannoy-Bruno
- , Chandani Desai
- & Jeffrey I. Gordon
-
Article
| Open AccessEvolutionary and biomedical insights from a marmoset diploid genome assembly
A trio-binning approach is used to produce a fully haplotype-resolved diploid genome assembly for the common marmoset, providing insight into the heterozygosity spectrum and the evolution of the sex-differentiation region.
- Chentao Yang
- , Yang Zhou
- & Guojie Zhang
-
Article |
Local immune response to food antigens drives meal-induced abdominal pain
In mice, oral tolerance to food antigens can break down after enteric infection, and this leads to food-induced pain resembling irritable bowel syndrome in humans.
- Javier Aguilera-Lizarraga
- , Morgane V. Florens
- & Guy E. Boeckxstaens
-
Article |
COVID-19 treatments and pathogenesis including anosmia in K18-hACE2 mice
Transgenic K18-hACE2 mice are a useful model of COVID-19 including anosmia; infection of these mice resulted in severe pneumonia and, in some cases, infection in the brain, which was prevented by convalescent plasma.
- Jian Zheng
- , Lok-Yin Roy Wong
- & Stanley Perlman
-
Article |
IGF1R is an entry receptor for respiratory syncytial virus
Respiratory syncytial virus enters cells by binding to cell-surface IGFR1, which activates PKCζ and induces trafficking of the NCL coreceptor to the RSV particles at the cell surface.
- Cameron D. Griffiths
- , Leanne M. Bilawchuk
- & David J. Marchant
-
Article |
Proteomics of SARS-CoV-2-infected host cells reveals therapy targets
SARS-CoV-2 modulates central cellular pathways, such as translation, splicing, carbon metabolism, proteostasis and nucleic acid metabolism, in human cells; these pathways can be inhibited by small-molecule inhibitors to prevent viral replication in the cells.
- Denisa Bojkova
- , Kevin Klann
- & Christian Münch
-
Article |
A calcineurin–Hoxb13 axis regulates growth mode of mammalian cardiomyocytes
Hoxb13 acts as a cofactor of Meis1 in regulating cardiomyocyte maturation and cell cycle, and knockout of both proteins enables regeneration of postnatal cardiac tissue in a mouse model of heart injury.
- Ngoc Uyen Nhi Nguyen
- , Diana C. Canseco
- & Hesham A. Sadek
-
Article |
Recapitulating the human segmentation clock with pluripotent stem cells
A system involving in vitro induction of presomitic mesoderm recapitulates oscillatory expression of core segmentation clock genes and travelling-wave-like gene expression, suggesting that this system can be used to study the human segmentation clock and provide insights into diseases associated with human axial skeletogenesis.
- Mitsuhiro Matsuda
- , Yoshihiro Yamanaka
- & Cantas Alev
-
Review Article |
Why and where an HIV cure is needed and how it might be achieved
Current barriers and limitations to HIV treatments are reviewed, and suggestions for future steps to achieve an effective curative intervention are discussed.
- Thumbi Ndung’u
- , Joseph M. McCune
- & Steven G. Deeks
-
Letter |
Syndecan 1 is a critical mediator of macropinocytosis in pancreatic cancer
In an inducible mouse model of pancreatic ductal adenocarcinoma, the signalling defect that underlies 90% of these tumours causes increased cell-surface expression of syndecan 1, leading to misregulation of macropinocytosis, and linking the defective signalling with nutrient-salvage pathways.
- Wantong Yao
- , Johnathon L. Rose
- & Giulio F. Draetta
-
Article |
Diabetes relief in mice by glucose-sensing insulin-secreting human α-cells
Islet non-β-cells from non-diabetic and diabetic human donors are modified via the transcription factors PDX1 and MAFA to produce and secrete insulin in response to glucose.
- Kenichiro Furuyama
- , Simona Chera
- & Pedro L. Herrera
-
Letter |
Sleep modulates haematopoiesis and protects against atherosclerosis
The fragmentation of sleep in Apoe−/− mice induces monocytosis and accelerated atherosclerosis due to a reduction in hypocretin that otherwise restricts bone marrow CSF1 availability.
- Cameron S. McAlpine
- , Máté G. Kiss
- & Filip K. Swirski
-
Brief Communications Arising |
The role of Olfr78 in the breathing circuit of mice
- Hortensia Torres-Torrelo
- , Patricia Ortega-Sáenz
- & José López-Barneo
-
Article |
Salt-responsive gut commensal modulates TH17 axis and disease
High salt intake changed the gut microbiome and increased TH17 cell numbers in mice, and reduced intestinal survival of Lactobacillus species, increased the number of TH17 cells and increased blood pressure in humans.
- Nicola Wilck
- , Mariana G. Matus
- & Dominik N. Müller
-
Article |
Autism gene Ube3a and seizures impair sociability by repressing VTA Cbln1
Increasing expression of the autism-associated gene Ube3a, either alone or in combination with seizures, not only impairs sociability in mice but also reduces expression of the synaptic organizer Cbln1 in the ventral tegmental area, thus weakening glutamatergic transmission.
- Vaishnav Krishnan
- , David C. Stoppel
- & Matthew P. Anderson
-
Letter |
Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice
A restricted diet extends the lives and improves the health of mice with accelerated ageing due to an inability to repair DNA damage.
- W. P. Vermeij
- , M. E. T. Dollé
- & J. H. J. Hoeijmakers
-
Perspective |
Accounting for reciprocal host–microbiome interactions in experimental science
This work highlights the critical challenges in experimental design and interpretation due to important combinatorial effects of host and microbial genes, and calls for the development of minimal reporting requirements to improve the interpretation and reproducibility of experimental biology.
- Thaddeus S. Stappenbeck
- & Herbert W. Virgin
-
Letter |
The Brazilian Zika virus strain causes birth defects in experimental models
- Fernanda R. Cugola
- , Isabella R. Fernandes
- & Patricia C. B. Beltrão-Braga
-
Letter |
Neutrophil ageing is regulated by the microbiome
Neutrophil ageing, which encourages inflammation and vaso-occlusion in a mouse model of sickle-cell disease, is shown to depend on the intestinal microbiota and activation of the TLR/Myd88 signalling pathways.
- Dachuan Zhang
- , Grace Chen
- & Paul S. Frenette
-
Article |
Loss of oncogenic Notch1 with resistance to a PI3K inhibitor in T-cell leukaemia
Mutations that dysregulate Notch1 and Ras/PI3K signalling are common in T-cell acute lymphoblastic leukaemia; here, treatment with a PI3K inhibitor is shown to induce drug resistance that is associated with downregulation of activated Notch1 signalling, suggesting that inhibition of both Notch1 and PI3K could promote drug resistance.
- Monique Dail
- , Jason Wong
- & Kevin Shannon
-
Letter |
Integrin-modulating therapy prevents fibrosis and autoimmunity in mouse models of scleroderma
Failure of integrin-mediated cell-matrix attachment is sufficient to initiate dermal fibrosis and autoimmunity in mouse models of scleroderma; integrin-modulating therapies prevent the recruitment and activation of plasmacytoid dendritic cells that appear central to immunological dysregulation and maintenance of the pro-fibrotic synthetic programme.
- Elizabeth E. Gerber
- , Elena M. Gallo
- & Harry C. Dietz
-
Letter |
The global distribution and burden of dengue
The public health burden of dengue is unknown; here cartographic approaches are used to provide insight into the global, regional and national burden of dengue, with the finding that the global number of infections per year is around 390 million, more than three times the estimate of the World Health Organization.
- Samir Bhatt
- , Peter W. Gething
- & Simon I. Hay
-
Research Highlights |
Alzheimer's in a dish