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| Open AccessA foundation model for generalizable disease detection from retinal images
RETFound, a foundation model for retinal images that learns generalizable representations from unlabelled images, is trained on 1.6 million unlabelled images by self-supervised learning and then adapted to disease detection tasks with explicit labels.
- Yukun Zhou
- , Mark A. Chia
- & Pearse A. Keane
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Article |
Interpericyte tunnelling nanotubes regulate neurovascular coupling
Retinal pericytes connect via interpericyte tunnelling nanotubes into functional syncytia that regulate microcirculatory blood flow to help to match local blood flow with neuronal activity.
- Luis Alarcon-Martinez
- , Deborah Villafranca-Baughman
- & Adriana Di Polo
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Brief Communications Arising |
Lens regeneration in children
- Demetrios G. Vavvas
- , Thaddeus P. Dryja
- & Scott R. Lambert
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Brief Communications Arising |
Improving outcomes in congenital cataract
- Ameenat Lola Solebo
- , Christopher J. Hammond
- & Jugnoo S. Rahi
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Article |
Lens regeneration using endogenous stem cells with gain of visual function
A new procedure for cataract removal that preserves lens epithelial progenitor cells in mammals, which require Pax6 and Bmi1 for their self-renewal, achieves lens regeneration in rabbits, macaques and in infants with cataracts.
- Haotian Lin
- , Hong Ouyang
- & Yizhi Liu
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Letter |
Co-ordinated ocular development from human iPS cells and recovery of corneal function
A protocol has been developed to use human induced pluripotent stem cells to obtain a self-formed ectodermal autonomous multizone, which includes distinct cell lineages of the eye, including the ocular surface ectoderm, lens, neuro-retina, and retinal pigment epithelium that can be expanded to form a functional corneal epithelium when transplanted to an animal model of corneal visual impairment.
- Ryuhei Hayashi
- , Yuki Ishikawa
- & Kohji Nishida
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Letter |
Lanosterol reverses protein aggregation in cataracts
Exploring the genetic basis of congenital cataracts in two families identifies a molecule, lanosterol, which prevents intracellular protein aggregation of various cataract-causing mutant crystallins, and which can reduce cataract severity and increase lens transparency in vivo in dogs.
- Ling Zhao
- , Xiang-Jun Chen
- & Kang Zhang
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Letter |
ABCB5 is a limbal stem cell gene required for corneal development and repair
The loss of limbal stem cells (LSCs) due to injury or disease is one of the leading causes of blindness; here, the ABCB5 protein is identified as a marker of LSCs in mouse and human eye, and shown to be functionally required for LSC maintenance, corneal development and repair.
- Bruce R. Ksander
- , Paraskevi E. Kolovou
- & Natasha Y. Frank
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- Conjunctival diseases
- Corneal diseases
- Eye abnormalities
- Eyelid diseases
- Hereditary eye disease
- Lacrimal apparatus diseases
- Lens diseases
- Macular degeneration
- Ocular hypertension
- Ocular ischemic syndrome
- Ocular motility disorders
- Optic nerve diseases
- Pupil disorders
- Refractive errors
- Retinal diseases
- Scleral diseases
- Uveal diseases
- Vision disorders
- Vitreous detachment