Featured
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Article |
Immune regulation by fungal strain diversity in inflammatory bowel disease
Genetically diverse Candida albicans strains in patients with inflammatory bowel disease secrete a toxin and aggravate IL-1β-dependent intestinal inflammation.
- Xin V. Li
- , Irina Leonardi
- & Iliyan D. Iliev
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Article |
Adaptive immunity induces mutualism between commensal eukaryotes
Studies of mouse and human IgA responses against Candida albicans and other common fungal species show that host adaptive immunity selects for fungal effectors that promote commensalism and prevent intestinal disease.
- Kyla S. Ost
- , Teresa R. O’Meara
- & June L. Round
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Letter |
Recognition of DHN-melanin by a C-type lectin receptor is required for immunity to Aspergillus
The C-type lectin receptor MelLec recognizes DHN-melanin in conidial spores of Aspergillus fumigatus and other DHN-melanized fungi, revealing an important role for this receptor in antifungal immunity in both mice and humans.
- Mark H. T. Stappers
- , Alexandra E. Clark
- & Gordon D. Brown
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Article |
Candidalysin is a fungal peptide toxin critical for mucosal infection
This study identifies a cytolytic peptide toxin in the opportunistic human fungal pathogen Candida albicans—the peptide is both a crucial virulence factor that permeabilizes the host cell plasma membrane and a key signal that triggers a host danger response pathway.
- David L. Moyes
- , Duncan Wilson
- & Julian R. Naglik
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Letter |
Fungal pathogen uses sex pheromone receptor for chemotropic sensing of host plant signals
Fungal pathogens reorient hyphal growth towards their plant hosts in response to chemical signals; here, directed growth of the plant pathogen Fusarium oxysporum towards the roots of the tomato plant is shown to be triggered by class III peroxidases secreted by the tomato plant, with the fungal response requiring a sex pheromone receptor.
- David Turrà
- , Mennat El Ghalid
- & Antonio Di Pietro
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Letter |
Amphibians acquire resistance to live and dead fungus overcoming fungal immunosuppression
The fungal pathogen Batrachochytrium dendrobatidis has been implicated in the decline of a large number of amphibian species; here it is shown that frogs can learn to avoid the pathogen, acquire resistance to it and be immunized against it using dead pathogen, findings that potentially offer a way in which resistant populations could be reintroduced into areas that have seen catastrophic declines.
- Taegan A. McMahon
- , Brittany F. Sears
- & Jason R. Rohr
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Letter |
Metabolic priming by a secreted fungal effector
- Armin Djamei
- , Kerstin Schipper
- & Regine Kahmann