Article
|
Open Access
Featured
-
-
Article
| Open Access
A saturated map of common genetic variants associated with human height
A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.
- Loïc Yengo
- , Sailaja Vedantam
- & Joel N. Hirschhorn
-
Article
| Open Access
Stroke genetics informs drug discovery and risk prediction across ancestries
A cross-ancestry meta-analysis of genome-wide association studies identifies association signals for stroke and its subtypes at 89 (61 new) independent loci, reveals putative causal genes, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as potential drug targets, and provides cross-ancestry integrative risk prediction.
- Aniket Mishra
- , Rainer Malik
- & Stephanie Debette
-
Article
| Open Access
The sequences of 150,119 genomes in the UK Biobank
To measure selection on variants, whole-genome sequencing of approximately 150,000 individuals from the UK Biobank is used to rank sequence variants by their level of depletion.
- Bjarni V. Halldorsson
- , Hannes P. Eggertsson
- & Kari Stefansson
-
Article |
Peroxiredoxins are conserved markers of circadian rhythms
Daily oxidation–reduction cycles of peroxiredoxin proteins are shown to be conserved in all domains of life, including Bacteria, Archaea and Eukaryota.
- Rachel S. Edgar
- , Edward W. Green
- & Akhilesh B. Reddy
-
News & Views |
Face of the past reconstructed
DNA is particularly well preserved in hair — enabling the genome of a human to be sequenced, and his ancestry and appearance to be determined, from 4,000-year-old remains.
- David M. Lambert
- & Leon Huynen
Genetic drivers of heterogeneity in type 2 diabetes pathophysiology