Geriatrics articles within Nature

Featured

  • Brief Communications Arising |

    • Xiao Dong
    • , Brandon Milholland
    •  & Jan Vijg

  • Letter |

    Demographic analysis of life expectancy and maximum reported age at death provides evidence that human lifespan has reached its natural limit.

    • Xiao Dong
    • , Brandon Milholland
    •  & Jan Vijg

  • Outlook |

    More people are surviving to older ages than ever before, pushing life expectancy from birth to unprecedented highs. Further gains will require tackling age-related conditions, across the world, with ramifications for society as a whole.

    • Tony Scully

  • Outlook |

    Treating cognitive problems common in elderly people requires a deeper understanding of how a healthy brain ages.

    • Alison Abbott

  • Outlook |

    Studies of gut bacteria are beginning to untangle how diet affects health in old age — but determining cause and effect is tricky.

    • Virginia Hughes

  • Outlook |

    High-tech gadgets such as sensors that detect falls and robots that can fetch items are helping people stay independent and safe into their later years.

    • Neil Savage

  • Outlook |

    Researchers are learning about the molecular basis of ageing — and finding clues about how to treat diseases in the process.

    • Katherine Bourzac

  • Outlook |

    Why do some people cope better than others with getting old? Sociologist Eva Kahana, director of the Elderly Care Research Center at Case Western Reserve University, offers some clues.

    • Rebecca Kessler

  • Outlook |

    Scientists are searching for a genetic blueprint that will enable humans to stay healthy and vital well into their old age.

    • Michael Eisenstein

  • Article |

    Here it is shown that telomere dysfunction drives metabolic and mitochondrial compromise. Mice with dysfunctional telomeres activate p53, which in turn represses PGC-1α and PGC-1β, master regulators of metabolic and mitochondrial processes. This results in reduced mitochondrial mass, mitochondrial dysfunction and reduced ATP generation, impaired gluconeogenesis, cariomyopathy and increased reactive oxygen species. This telomere–p53–PGC pathway shows how telomere dysfunction may compromise organ function and contribute to age-related disorders.

    • Ergün Sahin
    • , Simona Colla
    •  & Ronald A. DePinho

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