Featured
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Letter |
Palladium-mediated enzyme activation suggests multiphase initiation of glycogenesis
The mechanism of glycogenesis, initiated by glycogenin, involves three distinct kinetic phases, with the final phase involving a refining process where only glucose is tolerated as a substrate.
- Matthew K. Bilyard
- , Henry J. Bailey
- & Benjamin G. Davis
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Letter |
Comparative glycoproteomics of stem cells identifies new players in ricin toxicity
A novel quantitative approach to identify intact glycopeptides from comparative proteomic data sets, allowing inference of complex glycan structures and direct mapping of them to sites within the associated proteins at the proteome scale.
- Johannes Stadlmann
- , Jasmin Taubenschmid
- & Josef M. Penninger
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Letter |
LARGE glycans on dystroglycan function as a tunable matrix scaffold to prevent dystrophy
This study finds a direct correlation between LARGE-glycan extension on dystroglycan and the protein’s capacity for extracellular matrix ligands; in regenerating mouse muscle, short LARGE-glycan polysaccharides cause various defects, including muscle dysfunction and a predisposition to dystrophy, and in muscular dystrophy patients, increased clinical severity of disease corresponds to shorter LARGE-glycans.
- Matthew M. Goddeeris
- , Biming Wu
- & Kevin P. Campbell
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Letter |
Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation
CaMKII is known to be pathologically activated in heart failure and arrhythmias; here it is shown that glucose-induced CaMKII activation via O-linked glycosylation might contribute to cardiac pathology in diabetes.
- Jeffrey R. Erickson
- , Laetitia Pereira
- & Donald M. Bers
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Letter |
Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains
Several death-domain-containing proteins are directly inactivated by the enteropathogenic Escherichia coli type III secretion system effector NleB; NleB functions as an N-acetylglucosamine transferase that modifies a conserved death domain arginine residue, blocking the receptor–adapter interaction.
- Shan Li
- , Li Zhang
- & Feng Shao
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Article |
X-ray structure of a bacterial oligosaccharyltransferase
- Christian Lizak
- , Sabina Gerber
- & Kaspar P. Locher
Disruption of sugar nucleotide clearance is a therapeutic vulnerability of cancer cells