Granulocytes articles within Nature

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• Article
  12 December 2022 | Open Access

  Active eosinophils regulate host defence and immune responses in colitis

  Single-cell transcriptomic profiling and functional assays are used to identify subpopulations of eosinophils that are present in the mouse gastrointestinal tract and provide insight into the role of these cells in inflammatory bowel diseases in humans.

  • Alessandra Gurtner
  • , Costanza Borrelli
  •  & Isabelle C. Arnold

• Letter | 09 December 2015

  Neutrophils support lung colonization of metastasis-initiating breast cancer cells

  Neutrophils are shown to have a role in driving the metastasis of breast cancer cells to the lung, with neutrophil-derived leukotrienes promoting metastatic initiation in the lung by expanding the sub-pool of cancer cells with high tumorigenic potential.

  • Stefanie K. Wculek
  •  & Ilaria Malanchi

• Letter | 16 September 2015

  Neutrophil ageing is regulated by the microbiome

  Neutrophil ageing, which encourages inflammation and vaso-occlusion in a mouse model of sickle-cell disease, is shown to depend on the intestinal microbiota and activation of the TLR/Myd88 signalling pathways.

  • Dachuan Zhang
  • , Grace Chen
  •  & Paul S. Frenette

• Letter | 15 September 2013

  Type 2 innate lymphoid cells control eosinophil homeostasis

  Eosinophil recruitment to the lung and intestine is regulated by type-2-innate-lymphoid-cell-derived IL-5 and IL-13; IL-5 is shown to be induced by the neuropeptide vasoactive intestinal peptide, which is known to coordinate pancreatic secretion with smooth muscle relaxation in response to feeding.

  • Jesse C. Nussbaum
  • , Steven J. Van Dyken
  •  & Richard M. Locksley

• Letter | 01 July 2012

  ‘Slings’ enable neutrophil rolling at high shear

  During inflammation neutrophils roll along the vascular endothelium; here, previously unknown structures called ‘slings’, which appear and persist at the front of rolling cells in vivo and in vitro, are described.

  • Prithu Sundd
  • , Edgar Gutierrez
  •  & Klaus Ley

• Research Highlights | 14 March 2012

  Controlling natural killers

• Letter | 20 November 2011

  Lyn is a redox sensor that mediates leukocyte wound attraction in vivo

  The Src family kinase Lyn is identified as a physiological redox sensor that mediates the initial attraction of leukocytes to wounds in zebrafish larvae.

  • Sa Kan Yoo
  • , Taylor W. Starnes
  •  & Anna Huttenlocher

• Letter | 19 August 2010

  An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis

  Here, the human immune response to infection with Mycobacterium tuberculosis has been characterized by transcriptional profiling. The results show that active tuberculosis correlates with a particular transcriptional signature that is dominated by a neutrophil-driven interferon-inducible gene profile. The study provides a broad range of transcriptional biomarkers with potential as diagnostic and prognostic tools to combat the tuberculosis epidemic.

  • Matthew P. R. Berry
  • , Christine M. Graham
  •  & Anne O’Garra