Featured
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Letter |
Helios is a key transcriptional regulator of outer hair cell maturation
Ikzf2, which encodes the transcription factor Helios, is identified as a crucial regulator of gene expression in maturing cochlear outer hair cells, and overexpression of Ikzf2 in inner hair cells induces prestin expression and electromotility.
- Lauren Chessum
- , Maggie S. Matern
- & Ronna Hertzano
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Letter |
Trans-differentiation of outer hair cells into inner hair cells in the absence of INSM1
Conditional deletion of Insm1 in mice demonstrates that INSM1 is the key switch that causes the maturation of outer hair cells in the cochlea, with its absence resulting in an increase in inner hair cells instead.
- Teerawat Wiwatpanit
- , Sarah M. Lorenzen
- & Jaime García-Añoveros
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Letter |
Generation of inner ear sensory epithelia from pluripotent stem cells in 3D culture
A new approach has been developed in order to achieve the stepwise differentiation of inner ear sensory epithelia from mouse embryonic stem cells in a three-dimensional culture: this process, which mimics normal development and produces cells that have functional characteristics of mechanosensitive hair cells, is hoped to provide further insights into inner ear development and disorder.
- Karl R. Koehler
- , Andrew M. Mikosz
- & Eri Hashino
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Letter |
Multi-isotope imaging mass spectrometry reveals slow protein turnover in hair-cell stereocilia
Multi-isotope imaging mass spectrometry is used to quantify protein turnover in animal stereocilia, showing that rapid turnover occurs only in stereocilia tips.
- Duan-Sun Zhang
- , Valeria Piazza
- & Claude P. Lechene
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Research Highlights |
Culprit in deafness
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Letter |
Forces between clustered stereocilia minimize friction in the ear on a subnanometre scale
- Andrei S. Kozlov
- , Johannes Baumgart
- & A. J. Hudspeth
The conformational cycle of prestin underlies outer-hair cell electromotility