Hepatitis C virus articles within Nature

Featured

  • Article |

    Hepatitis C virus utilizes flavin adenine dinucleotide as a non-canonical initiating nucleotide for the viral RNA polymerase, resulting in 5′ capping of viral RNA, which provides protection against the host innate immune response.

    • Anna V. Sherwood
    • , Lizandro R. Rivera-Rangel
    •  & Jeppe Vinther

  • Article |

    Crystal structures of the hepatitis C virus (HCV) glycoprotein E2 in complex with CD81 reveal the conformational changes that occur in E2 after binding of CD81 and the effects of pH on binding affinity.

    • Ashish Kumar
    • , Reafa A. Hossain
    •  & Joseph Marcotrigiano

  • Letter |

    A CRISPR screening approach shows that endoplasmic reticulum (ER)-associated protein complexes, including the oligosaccharyltransferase (OST) protein complex, are important for infection by dengue virus and other related mosquito-borne flaviviruses, whereas hepatitis C virus is dependent on distinct entry factors, RNA binding proteins and FAD biosynthesis.

    • Caleb D. Marceau
    • , Andreas S. Puschnik
    •  & Jan E. Carette

  • Letter |

    The drug daclatasvir (DCV), which inhibits the hepatitis C virus (HCV) non-structural protein 5A (NS5A), can successfully reduce viral load in patients; here, a combination of DCV and an NS5A analogue is shown to enhance DCV potency on multiple genotypes and overcome resistance in vitro and in a mouse model.

    • Jin-Hua Sun
    • , Donald R. O’Boyle II
    •  & Min Gao

  • Letter |

    Hepatitis C virus cannot replicate in cell culture unless it possesses adaptive mutations; here, expression of cellular factor SEC14L2 is shown to allow replication of diverse hepatitis C virus genotypes in several hepatoma cell lines by enhancing vitamin E-mediated protection against lipid peroxidation.

    • Mohsan Saeed
    • , Ursula Andreo
    •  & Charles M. Rice

  • News & Views |

    Infection with hepatitis C is one of the main causes of liver disease, yet there are no broadly effective treatments. Discovery of a potent inhibitor of this virus shows that researchers must think outside the box.

    • Catherine L. Murray
    •  & Charles M. Rice

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