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Letter |
RAP2 mediates mechanoresponses of the Hippo pathway
The Ras-related GTPase RAP2 is a key intracellular signal transducer by which extracellular matrix rigidity controls mechanosensitive cellular activities through YAP and TAZ.
- Zhipeng Meng
- , Yunjiang Qiu
- & Kun-Liang Guan
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Letter |
Dystrophin–glycoprotein complex sequesters Yap to inhibit cardiomyocyte proliferation
After injury in the heart, postnatal mouse hearts deficient in the Hippo pathway show efficient repair, and in the hearts of Mdx mice (a model of Duchenne muscular dystrophy) Hippo deficiency protects against overload-induced heart failure.
- Yuka Morikawa
- , Todd Heallen
- & James F. Martin
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Letter |
The ligand Sas and its receptor PTP10D drive tumour-suppressive cell competition
Wild-type Drosophila epithelial cells outcompete proto-oncogenic cells through translocation of the ligand Sas to the wild-type–tumour cell interface, where it binds the PTP10D receptor of the tumour cell, initiating pro-apoptotic signalling.
- Masatoshi Yamamoto
- , Shizue Ohsawa
- & Tatsushi Igaki
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Letter |
Pitx2 promotes heart repair by activating the antioxidant response after cardiac injury
The transcription factor Pitx2 is upregulated in injured neonatal and Hippo-deficient mouse hearts, where it interacts with the Hippo effector protein Yap to activate reactive oxygen species scavengers, thus preventing the heart from oxidative damage.
- Ge Tao
- , Peter C. Kahr
- & James F. Martin
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Letter |
Mitochondrial defect drives non-autonomous tumour progression through Hippo signalling in Drosophila
In a Drosophila imaginal epithelial disc system, mutations that lead to mitochondrial dysfunction can also promote tumorigenic growth of neighbouring cells expressing an activated Ras oncogene.
- Shizue Ohsawa
- , Yoshitaka Sato
- & Tatsushi Igaki
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Hippo signalling maintains ER expression and ER+ breast cancer growth
Role of YAP/TAZ in mechanotransduction