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Open Access
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Allele-selective lowering of mutant HTT protein by HTT–LC3 linker compounds
Compounds that interact with mutant huntingtin and an autophagosomal protein are able to reduce cellular levels of mutant huntingtin by targeting it for autophagic degradation, demonstrating an approach that may have potential for treating proteopathies.
- Zhaoyang Li
- , Cen Wang
- & Boxun Lu
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Letter |
The cryo-electron microscopy structure of huntingtin
The structure of huntingtin in complex with an interactor is determined to an overall resolution of 4 Å, paving the way for improved understanding of the cellular functions of this protein.
- Qiang Guo
- , Bin Huang
- & Stefan Kochanek
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Letter |
Cystathionine γ-lyase deficiency mediates neurodegeneration in Huntington’s disease
Cystathionine γ-lyase, which is responsible for the production of cysteine, is decreased in the striatum and cortex of mouse models of Huntington’s disease and in patients with Huntington’s disease, and cysteine supplementation in diet and drinking water partly rescues the phenotype and the diminished longevity of the mouse model.
- Bindu D. Paul
- , Juan I. Sbodio
- & Solomon H. Snyder
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Outlook |
Neurodegeneration: Amyloid awakenings
Sleep disturbances may be an early sign of neurodegenerative diseases — but could sleep deficits cause these conditions in the first place?
- Moheb Costandi
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Research Highlights |
Silencing Huntington's gene
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Research Highlights |
Neurobiology: Neuronal housekeeping
m1A in CAG repeat RNA binds to TDP-43 and induces neurodegeneration