Imaging the immune system articles within Nature

Featured

  • Article
    | Open Access

    Studies in mice show that effector T regulatory cells in the gut are most functional in the lamina propria, but this homeostatic niche is disrupted in inflammation, suggesting a spatial mechanism of tolerance to commensal microorganisms.

    • Yisu Gu
    • , Raquel Bartolomé-Casado
    •  & Fiona Powrie

  • Article
    | Open Access

    This article describes a mechanism through which CD4+ T cells can eradicate MHC-deficient tumours that escape direct CD8+ T cell targeting and thereby complement the activity of CD8+ T cells and natural killer cells to advance cancer immunotherapies.

    • Bastian Kruse
    • , Anthony C. Buzzai
    •  & Thomas Tüting

  • Article
    | Open Access

    Skin tumour array by microporation (STAMP) captures the dynamic relationships of spatial, cellular and molecular components of tumour rejection and has the potential to translate therapeutic concepts into successful clinical strategies.

    • Guadalupe Ortiz-Muñoz
    • , Markus Brown
    •  & Christine Moussion

  • Article |

    High-dimensional datasets derived from time-resolved live imaging of leukocytes in mice were used to identify leukocyte identities and dynamic neutrophil states with high cellular resolution.

    • Georgiana Crainiciuc
    • , Miguel Palomino-Segura
    •  & Andrés Hidalgo

  • Article |

    Positron emission tomography measurements of nutrient uptake in cells of the tumour microenvironment reveal cell-intrinsic partitioning in which glucose uptake is higher in myeloid cells, whereas glutamine is preferentially acquired by cancer cells.

    • Bradley I. Reinfeld
    • , Matthew Z. Madden
    •  & W. Kimryn Rathmell

  • Article |

    A combination of fluorescent antibodies is used to build visual maps of all myeloid cells in the bone marrow, providing new insight into how the bone marrow microenvironment regulates cell-fate decisions.

    • Jizhou Zhang
    • , Qingqing Wu
    •  & Daniel Lucas

  • Article |

    The authors show that zonation extends to hepatic immune cells and that this spatial patterning is mediated by microbiome sensing by liver sinusoidal endothelial cells, and provide evidence that immune zonation is required to protect the host from the dissemination of blood-borne pathogens.

    • Anita Gola
    • , Michael G. Dorrington
    •  & Ronald N. Germain

  • Letter |

    Tracing the fate of circulating tumour cells by intravital two-photon lung imaging shows that tumours produce microparticles as they arrive and these migrate along the lung vasculature and are mostly taken up by interstitial myeloid cells, in a process that contributes to metastatic seeding; a minor subset of microparticles is engulfed by conventional dendritic cells, which are thought to contribute to the initiation of an anti-tumour immune response in lung-draining lymph nodes.

    • Mark B. Headley
    • , Adriaan Bins
    •  & Matthew F. Krummel

  • Article |

    Autoantigen-presenting dendritic cells are shown to interact with both effector and regulatory T cells, and effector-produced IL-2 activates the transcription factor STAT5 in regulatory T cells, which in turn upregulates suppressive molecules and prevents autoimmunity.

    • Zhiduo Liu
    • , Michael Y. Gerner
    •  & Ronald N. Germain

  • Letter |

    Interactions between T and B cells in the germinal centre are brief but involve extensive cell-surface contact in an entangled mode; ICOSL promotes T–B entanglement and B-cell acquisition of CD40L, which drives B cells to upregulate ICOSL, thus forming an intercellular feed-forward loop that is required for efficient positive selection and development of the bone marrow plasma cell compartment.

    • Dan Liu
    • , Heping Xu
    •  & Hai Qi

  • Letter |

    Here it is shown that T-cell receptors accumulate at the immunological synapse after stimulation with cognate antigen and are released in extracellular microvesicles by an ESCRT-dependent mechanism, the microvesicles deliver transcellular signals from CD4 T cells to antigen-presenting B cells and can induce B-cell signalling.

    • Kaushik Choudhuri
    • , Jaime Llodrá
    •  & Michael L. Dustin

  • Letter |

    Two-photon intravital imaging is used here to define the regulation of interstitial neutrophil migration at local sites of cell death upon sterile tissue injury and infection; leukotriene B4 (LTB4) is shown to act between neutrophils as a signal relay molecule that acts to enhance the radius of neutrophil recruitment within the inflamed interstitium, and also to control, in concert with integrin receptors, dense neutrophil clustering for tight wound seal formation.

    • Tim Lämmermann
    • , Philippe V. Afonso
    •  & Ronald N. Germain

  • Letter |

    Lymphocyte migration in the spleen is visualized live in mice using a real-time two-photon laser-scanning microscopy approach revealing that marginal zone and follicular B cells are highly motile and can shuttle between compartments, and integrin adhesion is the key to cellular retention in the marginal zone.

    • Tal I. Arnon
    • , Robert M. Horton
    •  & Jason G. Cyster

Browse broader subjects

Browse Imaging the immune system across other nature.com journals