Immune tolerance articles within Nature

Featured

• Article
  03 April 2024 | Open Access

  Immune microniches shape intestinal T_reg function

  Studies in mice show that effector T regulatory cells in the gut are most functional in the lamina propria, but this homeostatic niche is disrupted in inflammation, suggesting a spatial mechanism of tolerance to commensal microorganisms.

  • Yisu Gu
  • , Raquel Bartolomé-Casado
  •  & Fiona Powrie

• Article | 22 February 2023

  Autoimmunity in Down’s syndrome via cytokines, CD4 T cells and CD11c⁺ B cells

  An autoimmune-prone state of steady-state cytokinopathy, hyperactivated CD4 T cells and ongoing B cell activation contributes to a breach in immune tolerance in individuals with Down’s syndrome.

  • Louise Malle
  • , Roosheel S. Patel
  •  & Dusan Bogunovic

• Article
  07 September 2022 | Open Access

  Novel antigen-presenting cell imparts T_reg-dependent tolerance to gut microbiota

  Single-cell transcriptomic and epigenetic analysis has enabled the identification of Thetis cells, a class of RORγt⁺ antigen-presenting cells with a key role in the differentiation of commensal microbiota-induced peripheral regulatory T cells.

  • Blossom Akagbosu
  • , Zakieh Tayyebi
  •  & Chrysothemis C. Brown

• Article
  31 August 2022 | Open Access

  Dysregulated naive B cells and de novo autoreactivity in severe COVID-19

  Single-cell B cell repertoire analysis identifies the expansion of a naive-derived population of antibody-secreting cells contributing to de novo autoreactivity in patients with severe COVID-19 and those with post-COVID symptoms.

  • Matthew C. Woodruff
  • , Richard P. Ramonell
  •  & Ignacio Sanz

• Article
  27 April 2022 | Open Access

  TLR7 gain-of-function genetic variation causes human lupus

  The missense TLR7^Y264H gain-of-function genetic variation causes systemic lupus erythematosus in humans and mice.

  • Grant J. Brown
  • , Pablo F. Cañete
  •  & Carola G. Vinuesa

• Article | 02 March 2022

  Establishment of fetomaternal tolerance through glycan-mediated B cell suppression

  Pathways of glycan-mediated B cell suppression during pregnancy are important for promoting fetomaternal tolerance.

  • G. Rizzuto
  • , J. F. Brooks
  •  & A. Erlebacher

• Article | 13 January 2021

  Local immune response to food antigens drives meal-induced abdominal pain

  In mice, oral tolerance to food antigens can break down after enteric infection, and this leads to food-induced pain resembling irritable bowel syndrome in humans.

  • Javier Aguilera-Lizarraga
  • , Morgane V. Florens
  •  & Guy E. Boeckxstaens

• Letter | 27 February 2019

  Genome-wide analysis identifies NR4A1 as a key mediator of T cell dysfunction

  Tolerant T cells display characteristic patterns of gene expression and epigenetics that are distinct from other types of T cells and are orchestrated by the transcription factor NR4A1.

  • Xindong Liu
  • , Yun Wang
  •  & Chen Dong

• Letter | 18 July 2018

  Single-cell mapping of the thymic stroma identifies IL-25-producing tuft epithelial cells

  A comprehensive characterization of the thymic stroma identifies a tuft-cell-like thymic epithelial cell population that is critical for shaping the immune niche in the thymus.

  • Chamutal Bornstein
  • , Shir Nevo
  •  & Ido Amit

• Letter | 18 July 2018

  Pancreatic islets communicate with lymphoid tissues via exocytosis of insulin peptides

  A sensitive T cell tracking assay reveals immunogenic activity of specific catabolized peptide fragments of insulin and their effects on T cell activity in lymph nodes, highlighting communication between pancreatic islets and lymphoid tissue.

  • Xiaoxiao Wan
  • , Bernd H. Zinselmeyer
  •  & Emil R. Unanue

• Letter | 07 February 2018

  c-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont

  The transcription factor c-MAF is required for the generation of Helicobacter-specific regulatory T cells that selectively restrain pro-inflammatory T_H17 cells; the absence of c-MAF in mouse regulatory T cells results in pathobiont-dependent inflammatory bowel disease.

  • Mo Xu
  • , Maria Pokrovskii
  •  & Dan R. Littman

• Letter | 13 November 2013

  Themis sets the signal threshold for positive and negative selection in T-cell development

  This work shows that the Themis protein has a critical role in positive and negative thymocyte selection by dampening responses to low-affinity ligands but without affecting responses to high-affinity ligands, thus enabling positive selection of weakly self-reactive thymocytes.

  • Guo Fu
  • , Javier Casas
  •  & Nicholas R. J. Gascoigne

• News & Views | 03 October 2012

  Tolerating pregnancy

  The activity of specific suppressive immune cells, some of which persist to aid subsequent pregnancies, helps to explain how a pregnant female's immune system tolerates fetal antigens inherited from the father. See Letter p.102

  • Alexander G. Betz

• Letter | 26 September 2012

  Pregnancy imprints regulatory memory that sustains anergy to fetal antigen

  Successful pregnancy requires immune tolerance against paternal antigens expressed by the fetus; here pregnancy is shown to stimulate the selective accumulation of maternal immune-suppressive regulatory T cells with fetal specificity that are retained post-partum, which may explain the protective benefits of prior pregnancy against pre-eclampsia and other complications in subsequent pregnancy.

  • Jared H. Rowe
  • , James M. Ertelt
  •  & Sing Sing Way

• Letter | 19 August 2012

  Endogenous antigen tunes the responsiveness of naive B cells but not T cells

  Mature B cells encounter antigens during development that induce anergy or functional unresponsiveness; this large reservoir of dormant autoreactive B cells may serve as a pool of extended antibody specificity for purposes of protective immunity, as well as the source of pathogenic autoantibodies that characterize rheumatic diseases such as systemic lupus erythematosus.

  • Julie Zikherman
  • , Ramya Parameswaran
  •  & Arthur Weiss

• Outlook | 23 November 2011

  Treatment: In search of a booster shot

  A plethora of therapies can keep the symptoms of allergy under control, but they can't cure. New research aims to prevent allergies from developing in the first place.

  • Lauren Gravitz

• Letter | 21 September 2011

  Peripheral education of the immune system by colonic commensal microbiota

  • Stephanie K. Lathrop
  • , Seth M. Bloom
  •  & Chyi-Song Hsieh

• Letter | 13 July 2011

  Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T_reg cells

  • Andrea Facciabene
  • , Xiaohui Peng
  •  & George Coukos

• News & Views | 09 March 2011

  Context is key in the gut

  The vitamin-A metabolite retinoic acid normally favours immune tolerance in the gut. But in coeliac disease — an intestinal inflammatory disorder due to adverse reactivity to a dietary protein — it may do just the opposite. See Letter p.220

  • Craig L. Maynard
  •  & Casey T. Weaver

• Letter | 16 September 2010

  Inhibition of follicular T-helper cells by CD8⁺ regulatory T cells is essential for self tolerance

  Immune cells that recognize 'self' tissues need to be eliminated or controlled in order to prevent autoimmune diseases. Here, a T-cell population is delineated that is necessary to maintain self tolerance in mice. Genetic disruption of the inhibitory interaction between these CD8⁺ T cells and their target Qa-1⁺ follicular T-helper cells results in a lethal systemic-lupus-erythematosus-like autoimmune disease.

  • Hye-Jung Kim
  • , Bert Verbinnen
  •  & Harvey Cantor