Immunology articles within Polymer Journal

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• Focus Review | 23 March 2016

  Design of pH-sensitive polymer-modified liposomes for antigen delivery and their application in cancer immunotherapy

  The antigen-loaded liposomes modified with pH-sensitive polymers and adjuvants were taken up by dendritic cells and induced fusion with endosomal membranes, responding to the acidic pH inside of the endosomes, thus causing the transfer of the antigen into the cytosol, as shown in the fluorescence microscopic image (green: fluorescein isothiocyanate-labeled antigen, red: liposome). As a result, cross-presentation is promoted, leading to the induction of cellular immunity. In addition, the dendritic cells are activated by adjuvants, which causes the activation of cellular immunity, resulting in therapeutic effects on tumor-bearing mice.

  • Eiji Yuba

• Original Article | 11 July 2012

  The effects of carboxymethyl chitosan on the regulation of the proliferation, differentiation and cytokine expression of peripheral blood mononuclear cells

  Carboxymethyl chitosan(CMCTS), one of the chitosan derivates, is a zwitterion and potentially could be used as a kind of immunomodulator. The aim of this study is to investigate the immunological enhancement effects of CMCTS in vitro and provide an important theoretical evidence for its clinical practice.

  • Wenhua Xu
  • , Baoqin Han
  •  & Wanshun Liu