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Cognitive control persistently enhances hippocampal information processing
Studies in mice show that cognitive control training rapidly improves brain circuit function and enhances subsequent learning, which both persist for months.
- Ain Chung
- , Claudia Jou
- & André A. Fenton
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Article |
eIF2α controls memory consolidation via excitatory and somatostatin neurons
Stimulation of de novo protein synthesis in both excitatory and inhibitory, somatostatin-expressing neurons in the mouse hippocampus enhances memory consolidation.
- Vijendra Sharma
- , Rapita Sood
- & Nahum Sonenberg
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Letter |
Social behaviour shapes hypothalamic neural ensemble representations of conspecific sex
Interactions with male and female intruders activated overlapping neuronal populations in the ventromedial hypothalamus of inexperienced adult male mice, and these ensembles gradually separated as the mice acquired social and sexual experience with conspecifics.
- Ryan Remedios
- , Ann Kennedy
- & David J. Anderson
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Outlook |
Drug development: Illuminated targets
The development of effective antiepilepsy drugs is moving on from trial-and-error approaches to sophisticated molecular solutions.
- Megan Cully
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Letter |
Equalizing excitation–inhibition ratios across visual cortical neurons
Different amounts of excitation received by different pyramidal cells of primary visual cortex are matched by proportional amounts of inhibition.
- Mingshan Xue
- , Bassam V. Atallah
- & Massimo Scanziani
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Letter |
Oxytocin enhances hippocampal spike transmission by modulating fast-spiking interneurons
Oxytocin is shown to sharpen neuronal network activity by increasing fast-spiking interneuron activity.
- Scott F. Owen
- , Sebnem N. Tuncdemir
- & Richard W. Tsien
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Neocortical excitation/inhibition balance in information processing and social dysfunction
- Ofer Yizhar
- , Lief E. Fenno
- & Karl Deisseroth
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Lateral competition for cortical space by layer-specific horizontal circuits
A common anatomical feature of the sensory cortex in many species is that neurons with similar features cluster into vertically orientated domains spanning all layers of the cortex. Moreover, neurons in one domain modulate neurons in neighbouring domains through horizontal connections. A combination of techniques has now been used to show that such horizontal projections suppress layers of cortex devoted to processing inputs, but facilitate layers devoted to outputs.
- Hillel Adesnik
- & Massimo Scanziani
A NPAS4–NuA4 complex couples synaptic activity to DNA repair