Inhibition articles within Nature

Featured

  • Article |

    Novel experiences in mice lead to opposing effects on inhibition of Fos-activated hippocampal CA1 pyramidal neurons by parvalbumin- and cholecystokinin-expressing interneurons, revealing the roles of FOS and SCG2 in neural plasticity and consolidation of memories.

    • Ee-Lynn Yap
    • , Noah L. Pettit
    •  & Michael E. Greenberg

  • Article |

    A population of spinal interneurons that form axo–axonic connections with the terminals of proprioceptive afferents are shown to mediate presynaptic inhibition; their ablation elicits harmonic oscillations during goal-directed forelimb movements, which can be modelled as the consequence of an increase in sensory feedback gain.

    • Andrew J. P. Fink
    • , Katherine R. Croce
    •  & Eiman Azim

  • Article |

    Olfactory receptor neurons of fruitflies are shown to communicate with one another through ephaptic interactions with significant impact on olfactory behaviour; the results indicate that ephaptic effects may be more widespread than previously appreciated.

    • Chih-Ying Su
    • , Karen Menuz
    •  & John R. Carlson

  • News & Views Forum |

    Purkinje cells in the brain region known as the cerebellum act by inhibiting their target neurons. A paper in this issue provides an explanation for how this inhibition might be used to control the timing of action potentials. But experts are not equally convinced about the functional relevance of this finding. See Letter p.502

    • Javier F. Medina
    •  & Kamran Khodakhah

  • Letter |

    In the retina, highly selective wiring from inhibitory cells contributes to determine the direction-selection characteristics of an individual ganglion cell, yet how the asymmetric wiring inherent to these connections is established was unknown. Here, two independent studies using complementary techniques, including pharmacology, electrophysiology and optogenetics, find that although inhibitory inputs to both sides of the direction-selective cell are uniform early in development, by the second postnatal week, inhibitory synapses on the null side strengthen whereas those on the preferred side remain constant. These plasticity changes occur independent of neural activity, indicating that a specific developmental program is executed to produce the direction-selective circuitry in the retina.

    • Keisuke Yonehara
    • , Kamill Balint
    •  & Botond Roska

  • Letter |

    In the retina, highly selective wiring from inhibitory cells contributes to determine the direction-selection characteristics of an individual ganglion cell, yet how the asymmetric wiring inherent to these connections is established was unknown. Here, two independent studies using complementary techniques, including pharmacology, electrophysiology and optogenetics, find that although inhibitory inputs to both sides of the direction-selective cell are uniform early in development, by the second postnatal week, inhibitory synapses on the null side strengthen whereas those on the preferred side remain constant. These plasticity changes occur independent of neural activity, indicating that a specific developmental program is executed to produce the direction-selective circuitry in the retina.

    • Wei Wei
    • , Aaron M. Hamby
    •  & Marla B. Feller

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