Featured
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Letter |
Synthesis and breakdown of universal metabolic precursors promoted by iron
A chemical reaction network that overlaps with the biological Krebs and glyoxylate cycles arises from pyruvate and glyoxylate in the presence of iron, suggesting how early metabolic pathways might have arisen from CO2.
- Kamila B. Muchowska
- , Sreejith J. Varma
- & Joseph Moran
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Letter |
Regulation of mitochondrial morphology and function by stearoylation of TFR1
Mitochondria have essential functions within cells, and their dysfunction is linked to various disorders; here, the fatty acid stearic acid (C18:0), which is a dietary component, and the transferrin receptor (TFR1) are shown to regulate mitochondrial function.
- Deniz Senyilmaz
- , Sam Virtue
- & Aurelio A. Teleman
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Letter |
Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy
Through a quantitative proteomics analysis, a cohort of proteins is identified that associate with autophagosomes, among them a new cargo receptor called NCOA4 that, in response to iron deprivation, targets ferritin to autophagosomes and thereby releases iron.
- Joseph D. Mancias
- , Xiaoxu Wang
- & Alec C. Kimmelman
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Letter |
Structural insight into magnetochrome-mediated magnetite biomineralization
The magnetosome-associated protein mamP is an iron oxidase that reveals a unique arrangement of a self-plugged PDZ domain fused to two magnetochrome domains, defining a new class of c-type cytochrome exclusively found in magnetotactic bacteria.
- Marina I. Siponen
- , Pierre Legrand
- & David Pignol
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Letter |
Biomimetic assembly and activation of [FeFe]-hydrogenases
Three synthetic mimics of the di-iron centre in [FeFe]-hydrogenases are loaded onto the HydF protein and then transferred to apo-HydA1; full activation of HydA1 was achieved only with the HydF hybrid protein that contained the mimic with an azadithiolate bridge, confirming the presence of this ligand in the active site of native [FeFe]-hydrogenases.
- G. Berggren
- , A. Adamska
- & M. Fontecave
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Letter |
Preservation of organic matter in sediments promoted by iron
About one-fifth of organic carbon in sediments is bound to reactive iron phases, which are metastable over geological timescales and may therefore serve as a sink for the long-term storage of organic carbon.
- Karine Lalonde
- , Alfonso Mucci
- & Yves Gélinas
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Article |
Structural basis for iron piracy by pathogenic Neisseria
Structural analysis reveals the iron scavenging mechanism used by Neisseria species, involving TbpA and TbpB proteins, and sheds light on how human transferrin is specifically targeted.
- Nicholas Noinaj
- , Nicole C. Easley
- & Susan K. Buchanan
Structure of hepcidin-bound ferroportin reveals iron homeostatic mechanisms