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Super-resolution biomolecular crystallography with low-resolution data
X-ray crystallography has become the most common way for structural biologists to obtain the three-dimensional structures of proteins and protein complexes. However, crystals of large macromolecular complexes often diffract only weakly (yielding a resolution worse than 4 Å), so new methods that work at such low resolution are needed. Here a new method is described by which to obtain higher-quality electron density maps and more accurate molecular models of weakly diffracting crystals.
- Gunnar F. Schröder
- , Michael Levitt
- & Axel T. Brunger