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Open Access
Featured
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Article
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A foundation model for generalizable disease detection from retinal images
RETFound, a foundation model for retinal images that learns generalizable representations from unlabelled images, is trained on 1.6 million unlabelled images by self-supervised learning and then adapted to disease detection tasks with explicit labels.
- Yukun Zhou
- , Mark A. Chia
- & Pearse A. Keane
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Article
| Open Access
Blinded, randomized trial of sonographer versus AI cardiac function assessment
The impact of artificial intelligence in cardiac function assessment is evaluated by a blinded, randomized non-inferiority trial of artificial intelligence versus sonographer initial assessment of the left ventricular ejection fraction.
- Bryan He
- , Alan C. Kwan
- & David Ouyang
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Article
| Open Access
A wearable cardiac ultrasound imager
Innovations in device design, material fabrication and deep learning are described, leading to a wearable ultrasound transducer capable of dynamic cardiac imaging in various environments and under different conditions.
- Hongjie Hu
- , Hao Huang
- & Sheng Xu
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Matters Arising |
Reply to: Transparency and reproducibility in artificial intelligence
- Scott Mayer McKinney
- , Alan Karthikesalingam
- & Shravya Shetty
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Outlook |
Scans: Enhanced medical vision
The ability to look inside the human body without using a scalpel has revolutionized how we diagnose and treat illness and injury. By Brian Owens.
- Brian Owens
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Outlook |
Software: The computer will see you now
From image-analysis software to lens-free microscopes that fit on a mobile phone, new tools are providing pathologists with clearer and more informative images.
- Katherine Bourzac
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Outlook |
Inflammation: A complex problem
Multi-protein inflammasomes are being implicated in a surprising number of diseases, and researchers are keen to find out why.
- Katharine Gammon
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Outlook |
Next-generation scans: Seeing into the future
From magnetically tagged sugar to smoke-sensing surgical knives and beams of high-energy protons, the next wave of imaging technologies will provide a clearer view of the body.
- Peter Gwynne
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Outlook |
Technology: Multiple exposure
Combining imaging techniques can provide a wealth of information about disease.
- Neil Savage
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Outlook |
Surgery: The eyes of the operation
Real-time imaging of a patient's body is guiding surgeons and radiologists past healthy tissue to the diseased cells.
- Jessica Wright
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Outlook |
Alzheimer's disease: Mapping the brain's decline
Imaging the brains of Alzheimer's patients provides insights into the way this insidious disease progresses.
- Sarah C. P. Williams
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Outlook |
Perspective: The big picture
Many medical images are used once then filed away. This trove of clinical data should be made available to biomedical researchers, says Alan Moody.
- Alan Moody
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News |
Older people are more susceptible to swindlers
Brain scans reveal the elderly are worse than younger adults at picking out untrustworthy faces.
- Zoë Corbyn
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News |
Mammograms lead to unecessary diagnosis and treatment
Nearly one-third of breast cancers identified in healthy US women would never have caused symptoms.
- Meredith Wadman
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News |
Snapshots explore Einstein’s unusual brain
Photos reveal unique features of genius’s cerebral cortex.
- Mo Costandi
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News |
Brain scans of rappers shed light on creativity
Functional magnetic resonance imaging shows what happens in the brain during improvisation.
- Daniel Cressey
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Outlook |
Perspective: Brain scans need a rethink
Head movement can bias brain imaging results, undermining a leading theory on the cause of autism, say Ben Deen and Kevin Pelphrey.
- Ben Deen
- & Kevin Pelphrey
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Outlook |
Perspective: Imaging autism
Several studies in the past two years have claimed that brain scans can diagnose autism, but this assertion is deeply flawed, says Nicholas Lange.
- Nicholas Lange
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Outlook |
Diagnosis: Redefining autism
Draft diagnostic guidelines are raising concerns that mild forms of the disorder may no longer be recognized.
- Emily Singer
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News |
Scientists read dreams
Brain scans during sleep can decode visual content of dreams.
- Mo Costandi
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News Feature |
Neuroscience: Idle minds
Neuroscientists are trying to work out why the brain does so much when it seems to be doing nothing at all.
- Kerri Smith
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News Feature |
Neuroscience: The mind reader
Adrian Owen has found a way to use brain scans to communicate with people previously written off as unreachable. Now, he is fighting to take his methods to the clinic.
- David Cyranoski
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News & Views |
Crystal–clear brains
An ingenious technique allows the monitoring of brain-wide patterns of neuronal activity in a vertebrate at the cellular level, while the animal interacts with a virtual environment. See Article p.471
- Joseph R. Fetcho
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Research Highlights |
BOLD strides in brain imaging
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Q&A |
Turning point: Marc Modat
A postdoc’s development of a software code leads to numerous publications early in his career.
- Virginia Gewin
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Outlook |
Diagnostics: Getting a clear picture
Technologies that better reveal the insidious progression of multiple sclerosis could aid the search for treatments.
- Cynthia Graber
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News Feature |
Brain imaging: fMRI 2.0
Functional magnetic resonance imaging is growing from showy adolescence into a workhorse of brain imaging.
- Kerri Smith
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News |
Brain nerves line up neatly
Imaging study finds neural connections form regular grid.
- Helen Shen
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News Feature |
Neuroscience: Making connections
Is a project to map the brain’s full communications network worth the money?
- Jon Bardin
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World View |
Clear up this fuzzy thinking on brain scans
France has banned commercial applications of brain imaging. So why approve its use in court, asks Olivier Oullier.
- Olivier Oullier
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News |
Souped-up cyclotrons offer isotope remedy
Approach could avert shortage of valuable tracers for medical imaging.
- Nicola Jones
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Outlook |
Imaging: Seeing is believing
New technology to peer into the bones could help improve the treatment of multiple myeloma patients.
- Cassandra Willyard
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Research Highlights |
Moving micro magnets
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News |
Glowing cells guide cancer surgeons
Tumour-specific label pinpoints malignant cells.
- Zoe Cormier
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News & Views |
50 & 100 years ago
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News |
Alzheimer's-disease probe nears approval
Imaging technique could help to resolve questions about brain plaques associated with the condition.
- Heidi Ledford
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Research Highlights |
Ringing in the brain
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News |
Video microscopy reveals molecules in motion
Technique tracks chemicals in living tissues without the need for fluorescent labels.
- Heidi Ledford
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Perspective |
From maps to mechanisms through neuroimaging of schizophrenia
- Andreas Meyer-Lindenberg
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News |
Star Wars-style holograms: a new hope?
Novel plastic could enable real-time 3D holographic projections.
- Zeeya Merali
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News |
Surprise diagnoses for research volunteers
Test scans of the abdomen and brain show high rates of abnormalities.
- Janelle Weaver
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Letter |
Ptychographic X-ray computed tomography at the nanoscale
Ptychographic X-ray imaging is a powerful technique for extracting detailed phase (and hence structural) information from weakly absorbing objects. Here it is shown how this technique can be combined with methods for tomographic reconstruction to generate full three-dimensional maps of the object under investigation. The approach has sensitivity to density variations of less than one per cent, and can resolve structures on the 100 nm length scale.
- Martin Dierolf
- , Andreas Menzel
- & Franz Pfeiffer
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News & Views |
A new phase for X-ray imaging
A fine marriage between two approaches to X-ray microscopy — computed tomography and ptychographic imaging — delivers high-resolution, three-dimensional images of samples without the need for lenses. See Letter p. 436
- Henry N. Chapman
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Outlook |
Biomarkers: casting the net wide
To have any hope of affecting the course of Parkinson's disease, early diagnosis is essential. Rachel Jones assesses progress so far.
- Rachel Jones
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News |
Brain-imaging programme suspended after violations
FDA investigation at Columbia University serves as warning to other centres, say experts.
- Brendan Borrell
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News |
MRI set to win reprieve from EU ban
Directive that limits workers' electromagnetic exposure aims for a compromise.
- Alison Abbott
Normative spatiotemporal fetal brain maturation with satisfactory development at 2 years