Featured
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Aged skeletal stem cells generate an inflammatory degenerative niche
An analysis of skeletal stem cells in mice reveals that bone ageing occurs at the level of local niches affecting skeletal and haematopoietic lineage output, which may influence systemic aspects of multi-organ physiological ageing.
- Thomas H. Ambrosi
- , Owen Marecic
- & Charles K. F. Chan
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Article |
Lipid availability determines fate of skeletal progenitor cells via SOX9
Lipid starvation results in skeletal progenitors favouring commitment to chondrogenic over osteogenic fate, a process mediated by FOXO transcription factors and SOX9.
- Nick van Gastel
- , Steve Stegen
- & Geert Carmeliet
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Letter |
Resting zone of the growth plate houses a unique class of skeletal stem cells
In a mouse model, PTHrP-positive chondrocytes in the resting zone of the growth plate constitute a unique stem-cell population, which is initially unipotent and makes columnar chondrocytes that later exhibit multipotency.
- Koji Mizuhashi
- , Wanida Ono
- & Noriaki Ono
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Letter |
Discovery of a periosteal stem cell mediating intramembranous bone formation
A periosteal stem cell specialized in intramembranous bone formation has been identified and was found to be essential for normal bone development and fracture healing.
- Shawon Debnath
- , Alisha R. Yallowitz
- & Matthew B. Greenblatt
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Letter |
A stromal cell population that inhibits adipogenesis in mammalian fat depots
Single-cell transcriptomics reveals that, in mice and humans, a population of cells in the stromal vascular fraction of adipose tissue regulates adipogenesis by suppressing adipocyte formation in a paracrine manner.
- Petra C. Schwalie
- , Hua Dong
- & Bart Deplancke
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Letter |
Intronic polyadenylation of PDGFRα in resident stem cells attenuates muscle fibrosis
Changes in intronic polyadenylation of the Pdgfra in fibro/adipogenic progenitors lead to increased expression of a shorter variant with a truncated kinase domain, which modulates pro-fibrotic pathways to reduce tissue fibrosis in muscle.
- Alisa A. Mueller
- , Cindy T. van Velthoven
- & Thomas A. Rando
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Letter |
Glial origin of mesenchymal stem cells in a tooth model system
In the mouse, nerve-associated peripheral glial cells give rise to mesenchymal stem cells that contribute to the development and growth of adult teeth.
- Nina Kaukua
- , Maryam Khatibi Shahidi
- & Igor Adameyko
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Letter |
Foxc1 is a critical regulator of haematopoietic stem/progenitor cell niche formation
Transcription factor Foxc1 is a key regulator of haematopoietic stem/progenitor cell niche formation.
- Yoshiki Omatsu
- , Masanari Seike
- & Takashi Nagasawa
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Letter |
Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat
A shortage of constitutive brown adipose tissue is shown to result when brown adipogenic progenitor cells lack a type of BMP receptor; however, this leads to an increase in sympathetic input to white adipose tissue and a compensatory browning of white fat depots.
- Tim J. Schulz
- , Ping Huang
- & Yu-Hua Tseng
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Article |
Mesenchymal and haematopoietic stem cells form a unique bone marrow niche
The identity of the cells that form the haematopoietic stem cell (HSC) niche in bone marrow has been unclear. These authors identify nestin-expressing mesenchymal stem cells as niche-forming cells. These nestin-expressing cells show a close physical association with HSCs and express high levels of genes involved in HSC maintenance, and their depletion reduces bone marrow homing of haematopoietic progenitors.
- Simón Méndez-Ferrer
- , Tatyana V. Michurina
- & Paul S. Frenette
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Letter |
Rb regulates fate choice and lineage commitment in vivo
The retinoblastoma tumour suppressor protein pRb can suppress the activity of certain transcription factors and potentiate the activity of others, and has been shown to affect the differentiation of different cell lineages in vitro. These authors show that the Rb gene has a role in driving bone cell formation or brown adipose tissue formation in vivo.
- Eliezer Calo
- , Jose A. Quintero-Estades
- & Jacqueline A. Lees
A multi-stem cell basis for craniosynostosis and calvarial mineralization