Mesoderm articles within Nature

Featured

  • Article |

    Somitoids and segmentoids—culture systems that recapitulate the formation of somite-like structures—reveal that an initial salt-and-pepper expression pattern of MESP2 in a newly formed segment is transformed into compartments of anterior and posterior identity through an active cell-sorting mechanism.

    • Yuchuan Miao
    • , Yannis Djeffal
    •  & Olivier Pourquié

  • Article |

    The zebrafish segmentation clock drives sequential segmentation of somites by periodically lowering double-phosphorylated Erk and therefore projecting its oscillation on the double-phosphorylated Erk gradient.

    • M. Fethullah Simsek
    • , Angad Singh Chandel
    •  & Ertuğrul M. Özbudak

  • Article |

    The single-cell transcriptional profile of a human embryo between 16 and 19 days after fertilization reveals parallels and differences in gastrulation in humans as compared with mouse and non-human primate models.

    • Richard C. V. Tyser
    • , Elmir Mahammadov
    •  & Shankar Srinivas

  • Article |

    Single-cell RNA sequencing and spatial transcriptomics reveal that the somitogenesis clock is active in mouse gastruloids, which can be induced to generate somites with the correct rostral–caudal patterning.

    • Susanne C. van den Brink
    • , Anna Alemany
    •  & Alexander van Oudenaarden

  • Article |

    Human presomitic mesoderm cells derived in vitro demonstrate oscillations of the segmentation clock, thus providing a window into an otherwise inaccessible stage of human development.

    • Margarete Diaz-Cuadros
    • , Daniel E. Wagner
    •  & Olivier Pourquié

  • Article |

    Monitoring cells of the mouse presomitic mesoderm using the Achilles reporter fused to HES7 sheds light on the mechanisms that underpin synchronous oscillations in the expression of clock genes between neighbouring cells.

    • Kumiko Yoshioka-Kobayashi
    • , Marina Matsumiya
    •  & Ryoichiro Kageyama

  • Letter |

    An ex vivo primary culture assay is developed that recapitulates mouse embryonic mesodermal patterning and segment formation; using this approach, it is shown that oscillating gene activity is central to maintain stable proportions during development.

    • Volker M. Lauschke
    • , Charisios D. Tsiairis
    •  & Alexander Aulehla

  • Letter |

    The blood–brain barrier (BBB) is made up of vascular endothelial cells and was thought to have formed postnatally from astrocytes. Two independent studies demonstrate that this barrier forms during embryogenesis, with pericyte/endothelial cell interactions being critical to regulate the BBB during development. A better understanding of the relationship among pericytes, neuroendothelial cells and astrocytes in BBB function will contribute to our understanding of BBB breakdown during central nervous system injury and disease.

    • Annika Armulik
    • , Guillem Genové
    •  & Christer Betsholtz

  • Letter |

    The vertebrate body plan shows marked bilateral symmetry, although this can be disrupted in conditions such as scoliosis. Here, a mutation in Rere is found that leads to the formation of asymmetrical somites in mouse embryos; furthermore, Rere is shown to control retinoic acid signalling, which is required to maintain somite symmetry by interacting with Fgf8. The results provide insight into how bilateral symmetry is maintained.

    • Gonçalo C. Vilhais-Neto
    • , Mitsuji Maruhashi
    •  & Olivier Pourquié

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