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APOE4/4 is linked to damaging lipid droplets in Alzheimer’s disease microglia
A microglial state, featuring lipid droplets and secretion of neurotoxic factors, is shown to be most prominent in people with Alzheimer’s disease who have the APOE4 genotype.
- Michael S. Haney
- , Róbert Pálovics
- & Tony Wyss-Coray
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Article
| Open Access
Microglia regulate central nervous system myelin growth and integrity
Resident microglia in the central nervous system are identified as the specific macrophage population that regulates myelin growth and integrity.
- Niamh B. McNamara
- , David A. D. Munro
- & Veronique E. Miron
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Article |
Prenatal immune stress blunts microglia reactivity, impairing neurocircuitry
Aberrantly formed microglia due to an adverse prenatal environment affect long-term microglia reactivity and proper striatal circuit development in mice
- Lindsay N. Hayes
- , Kyongman An
- & Akira Sawa
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Article |
Pyramidal neuron subtype diversity governs microglia states in the neocortex
Spatial and single-cell transcriptomic characterization of microglia in the mouse somatosensory cortex show that the state of these cells is determined by signals from diverse surrounding neurons.
- Jeffrey A. Stogsdill
- , Kwanho Kim
- & Paola Arlotta
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Article |
Microglia-organized scar-free spinal cord repair in neonatal mice
In neonatal mice, scar-free healing after spinal cord injury is organized by microglia, and transplantation of neonatal microglia or peptidase-inhibitor-treated adult microglia into adult mice after injury improves healing and axon regrowth.
- Yi Li
- , Xuelian He
- & Zhigang He
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Article |
Negative feedback control of neuronal activity by microglia
Microglia, the brain’s immune cells, suppress neuronal activity in response to synaptic ATP release and alter behavioural responses in mice.
- Ana Badimon
- , Hayley J. Strasburger
- & Anne Schaefer
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Article |
Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency
In the absence of progranulin, microglia enter a disease-specific state that causes endolysosomal dysfunction and neurodegeneration, and these microglia promote TDP-43 granule formation, nuclear pore defects and cell death specifically in excitatory neurons via the complement activation pathway.
- Jiasheng Zhang
- , Dmitry Velmeshev
- & Eric J. Huang
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Letter |
Microglia-dependent synapse loss in type I interferon-mediated lupus
Abnormal behavioural phenotypes and synapse loss in the brain of lupus-prone mice are prevented by blocking type I interferon signalling, which is further shown to stimulate microglial phagocytosis of neuronal material in the brains of these mice.
- Allison R. Bialas
- , Jessy Presumey
- & Michael C. Carroll
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Letter |
TAM receptors regulate multiple features of microglial physiology
Microglial phagocytosis is required for neurogenic niche maintenance and response to injury; the TAM kinases Mer and Axl are expressed by microglia in the adult CNS, and mediate the clearance of apoptotic cells from the niche.
- Lawrence Fourgeaud
- , Paqui G. Través
- & Greg Lemke
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News Feature |
Microglia: The constant gardeners
Once thought to be passive sentinels, microglia now seem to be crucial for pruning back neurons during development.
- Virginia Hughes
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News |
Nanomaterials offer hope for cerebral palsy
Rabbits with brain injuries hop again after treatment with dendrimers.
- Amy Maxmen
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Letter |
Wild-type microglia arrest pathology in a mouse model of Rett syndrome
Transplanting bone marrow from wild-type mice into MECP2-lacking mice results in wild-type microglial engraftment, extends lifespan and reduces symptoms of disease such as breathing and locomotor abnormalities, implicating microglia in the pathophysiology of Rett syndrome.
- Noël C. Derecki
- , James C. Cronk
- & Jonathan Kipnis
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Article |
Caspase signalling controls microglia activation and neurotoxicity
- Miguel A. Burguillos
- , Tomas Deierborg
- & Bertrand Joseph
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Research Highlights |
Neurobiology: Trimming brain connections
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Review Article |
The myeloid cells of the central nervous system parenchyma
- Richard M. Ransohoff
- & Astrid E. Cardona
Mitochondrial complex I activity in microglia sustains neuroinflammation