Featured
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Perspective |
The power and potential of mitochondria transfer
The mechanisms by which mitochondria are transferred between cells and how intercellular mitochondria transfer regulates physiological processes and disease pathogenesis are discussed.
- Nicholas Borcherding
- & Jonathan R. Brestoff
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Article |
The γδ IEL effector API5 masks genetic susceptibility to Paneth cell death
Intraepithelial lymphocytes expressing γ and δ T cell receptor subunits protect Paneth cells from cell death caused by viral infection or Crohn's disease.
- Yu Matsuzawa-Ishimoto
- , Xiaomin Yao
- & Ken Cadwell
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Article |
Distinct fission signatures predict mitochondrial degradation or biogenesis
Mitochondrial fission at the organelle periphery generates small daughter mitochondria that are removed by mitophagy whereas fission at the midzone leads to proliferation.
- Tatjana Kleele
- , Timo Rey
- & Suliana Manley
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Article |
The ADP/ATP translocase drives mitophagy independent of nucleotide exchange
A CRISPR–Cas9 genetic screen shows that the adenine nucleotide translocator is required for mitophagy and that this role is independent of its nucleotide translocase activity.
- Atsushi Hoshino
- , Wei-jia Wang
- & Zoltan Arany
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Letter |
Asymmetric lysosome inheritance predicts activation of haematopoietic stem cells
The cellular degradative machinery can be asymmetrically inherited upon haematopoietic-stem-cell division, which predicts the future metabolic and translational activation of their daughter cells.
- Dirk Loeffler
- , Arne Wehling
- & Timm Schroeder
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Article |
The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy
The PINK1 ubiquitin kinase is shown to recruit the two autophagy receptors NDP52 and OPTN to mitochondria to activate mitophagy directly, independently of the ubiquitin ligase parkin; once recruited to mitochondria, NDP52 and OPTN recruit autophagy initiation components, and parkin may amplify the phospho-ubiquitin signal generated by PINK1, resulting in robust autophagy induction.
- Michael Lazarou
- , Danielle A. Sliter
- & Richard J. Youle
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Letter |
High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy
Mitophagy is the elimination of damaged mitochondria by the autophagosome regulated by the ubiquitin ligase, parkin and the kinase PINK1; a genome-wide RNAi screen with high-content microscopy has identified new genes that have an upstream role in parkin translocation to the mitochondria.
- Samuel A. Hasson
- , Lesley A. Kane
- & Richard J. Youle
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Letter |
Image-based genome-wide siRNA screen identifies selective autophagy factors
- Anthony Orvedahl
- , Rhea Sumpter Jr.
- & Beth Levine
Mitochondrial transfer mediates endothelial cell engraftment through mitophagy