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Molecular fluctuations are random changes of molecular parameters such as conformation or concentration. In living cells, molecular fluctuations are a source of heterogeneity among cells sharing a common genetic background.
Combined transcriptomics and proteomics of skin and lymphoid organs reveal the significance of SPINK5 in the regulation of protease activity and systemic inflammation, providing a conserved molecular framework for Netherton syndrome.
Signalling responses are marked by substantial cell-to-cell variability. Here, the authors propose an information theoretic framework that accounts for multiple inputs and temporal dynamics to analyse how signals flow through shared network components.
A diet-controlled study indicates that metabolic flexibility is an important driver of inter-individual difference in the response to dietary change, and a high flexibility score is a likely health asset.