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Article
| Open Access
A somato-cognitive action network alternates with effector regions in motor cortex
Functional MRI studies across ages show that the classic homunculus of the motor cortex in humans is in fact discontinuous, alternating with action control-linked regions termed the somato-cognitive action network.
- Evan M. Gordon
- , Roselyne J. Chauvin
- & Nico U. F. Dosenbach
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Article
| Open Access
Cortical–hippocampal coupling during manifold exploration in motor cortex
A new study explores the activity dialogue between hippocampus and cortex as neuronal representations of learning or adaptation are consolidated.
- Jaekyung Kim
- , Abhilasha Joshi
- & Karunesh Ganguly
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Cortical processing of flexible and context-dependent sensorimotor sequences
A sequence licking task reveals a set of key cortical regions for the coding of movement sequences in mice.
- Duo Xu
- , Mingyuan Dong
- & Daniel H. O’Connor
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Cortical preparatory activity indexes learned motor memories
In rhesus monkeys, learning of a motor task is accompanied by uniform changes in preparatory activity in motor cortex that are orthogonal to the force-predictive neural state subspace.
- Xulu Sun
- , Daniel J. O’Shea
- & Krishna V. Shenoy
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Article
| Open Access
A transcriptomic and epigenomic cell atlas of the mouse primary motor cortex
The authors describe an integrated atlas of the diverse cell types in the mouse primary motor cortex.
- Zizhen Yao
- , Hanqing Liu
- & Eran A. Mukamel
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Article
| Open Access
Cellular anatomy of the mouse primary motor cortex
Multi-modal analysis is used to generate a 3D atlas of the upper limb area of the mouse primary motor cortex, providing a framework for future studies of motor control circuitry.
- Rodrigo Muñoz-Castañeda
- , Brian Zingg
- & Hong-Wei Dong
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Article
| Open Access
Isoform cell-type specificity in the mouse primary motor cortex
- A. Sina Booeshaghi
- , Zizhen Yao
- & Lior Pachter
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Article
| Open Access
A multimodal cell census and atlas of the mammalian primary motor cortex
The BRAIN Initiative Cell Census Network has constructed a multimodal cell census and atlas of the mammalian primary motor cortex in a landmark effort towards understanding brain cell-type diversity, neural circuit organization and brain function.
- Edward M. Callaway
- , Hong-Wei Dong
- & Susan Sunkin
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Cortex-dependent corrections as the tongue reaches for and misses targets
Three-dimensional imaging of the lingual kinematics of mice drinking from a water spout reveals that successful licks have the hallmarks of online motor control, requiring rapid adjustments controlled by anterolateral motor cortex.
- Tejapratap Bollu
- , Brendan S. Ito
- & Jesse H. Goldberg
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High-performance brain-to-text communication via handwriting
A brain–computer interface enables rapid communication through neural decoding of attempted handwriting movements in a person with paralysis.
- Francis R. Willett
- , Donald T. Avansino
- & Krishna V. Shenoy
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Cortical pattern generation during dexterous movement is input-driven
The complex patterns of activity in motor cortex that control movements such as reach and grasp are dependent on both upstream neuronal activity in the thalamus and the current state of the cortex.
- Britton A. Sauerbrei
- , Jian-Zhong Guo
- & Adam W. Hantman
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Distinct descending motor cortex pathways and their roles in movement
Transcriptional profiling and axonal reconstructions identify two types of pyramidal tract neuron in the motor cortex: one type projects to thalamic regions and produces early and persistent preparatory activity, and the other type projects to motor centres in the medulla and produces motor commands.
- Michael N. Economo
- , Sarada Viswanathan
- & Karel Svoboda
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Letter |
Emergence of reproducible spatiotemporal activity during motor learning
Inhibitory neuron activity is found to be relatively stable during motor learning whereas excitatory neuron activity is much more dynamic — the results indicate that a large number of neurons exhibit activity changes early on during motor learning, but this population is refined with subsequent practice.
- Andrew J. Peters
- , Simon X. Chen
- & Takaki Komiyama
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Neural population dynamics during reaching
- Mark M. Churchland
- , John P. Cunningham
- & Krishna V. Shenoy
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Letter |
Repetitive motor learning induces coordinated formation of clustered dendritic spines in vivo
Repetitive activation of specific circuitry in the motor cortex during motor learning can induce new clusters of dendritic spines to form, which are preferentially stabilized during prolonged learning sessions.
- Min Fu
- , Xinzhu Yu
- & Yi Zuo
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Letter |
Primary motor cortex underlies multi-joint integration for fast feedback control
- J. Andrew Pruszynski
- , Isaac Kurtzer
- & Stephen H. Scott
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Letter |
Learning-related fine-scale specificity imaged in motor cortex circuits of behaving mice
It is generally accepted that specific neuronal circuits in the brain's cortex drive behavioural execution, but the relationship between the performance of a task and the function of a circuit is unknown. Here, this problem was tackled by using a technique that allows many neurons within the same circuit to be monitored simultaneously. The findings indicate that enhanced correlated activity in specific ensembles of neurons can identify and encode specific behavioural responses while a task is learned.
- Takaki Komiyama
- , Takashi R. Sato
- & Karel Svoboda
A high-performance neuroprosthesis for speech decoding and avatar control