Multipotent stem cells articles within Nature

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• Letter | 28 November 2018

  Mechanosignalling via integrins directs fate decisions of pancreatic progenitors

  Single-cell analysis reveals that interactions with the extracellular matrix via integrin α5 and mechanotransducer YAP1 determine whether pancreatic progenitors develop along the duct or endocrine lineages.

  • Anant Mamidi
  • , Christy Prawiro
  •  & Henrik Semb

• Letter | 03 January 2018

  Hierarchically related lineage-restricted fates of multipotent haematopoietic stem cells

  Analysis of transplantation of single haematopoietic stem cells in mice defines stable lineage-restricted fates in long-term self-renewing multipotent stem cells, including a class of multipotent stem cells that exclusively replenishes the megakaryocyte/platelet lineage.

  • Joana Carrelha
  • , Yiran Meng
  •  & Sten Eirik W. Jacobsen

• Letter | 19 August 2010

  Microenvironmental reprogramming of thymic epithelial cells to skin multipotent stem cells

  The thymus contains thymic epithelial cells (TECs), which form a complex three-dimensional network organized into cortical and medullary compartments. It is shown here that these cells are plastic. Clonogenic TECs can acquire new properties when exposed to the skin microenvironment; under such conditions, they can permanently adopt the fate of hair follicle multipotent stem cells. Hence, microenvironmental cues can be sufficient to re-direct epithelial cell fate.

  • Paola Bonfanti
  • , Stéphanie Claudinot
  •  & Yann Barrandon

• Letter | 01 April 2010

  IL25 elicits a multipotent progenitor cell population that promotes T_H2 cytokine responses

  Several non-haematopoietic-cell-derived cytokines, including interleukin (IL)25, have been implicated in inducing T helper 2 (T_H2) cell-dependent inflammation, but their precise role has been unclear. Here, IL25 is shown to promote the accumulation of multipotent progenitor cells in gut-associated lymphoid tissue. These cells can give rise to macrophage or granulocyte lineages that promote the differentiation of T_H2 cells and contribute to protective immunity against helminth infections.

  • Steven A. Saenz
  • , Mark C. Siracusa
  •  & David Artis