Featured
-
-
Article |
An IL-4 signalling axis in bone marrow drives pro-tumorigenic myelopoiesis
Single-cell transcriptomics studies on human and mouse non-small cell lung cancer and conditional knockout mouse models show that IL-4 from bone marrow basophils drives the development of granulocyte-monocyte progenitors to myeloid cells that suppress antitumour immunity.
- Nelson M. LaMarche
- , Samarth Hegde
- & Miriam Merad
-
Review Article |
Physiology and diseases of tissue-resident macrophages
This Review addresses the current understanding of the roles of tissue-resident macrophages in physiology and disease, including their development and their functions in tissue remodelling and nutrient recycling.
- Tomi Lazarov
- , Sergio Juarez-Carreño
- & Frederic Geissmann
-
Article |
Independent origins of fetal liver haematopoietic stem and progenitor cells
In fetal liver, the structure of the differentiated haemapoietic progenitor cell population is established directly from precursor cells, independently of haemapoietic stem cells.
- Tomomasa Yokomizo
- , Takako Ideue
- & Toshio Suda
-
Article |
Ablation of cDC2 development by triple mutations within the Zeb2 enhancer
The transcription factor NFIL3 acts antagonistically to C/EBP proteins by binding the Zeb2 enhancer to prevent Zeb2 expression and the development of the conventional type 2 dendritic cell lineage.
- Tian-Tian Liu
- , Sunkyung Kim
- & Kenneth M. Murphy
-
Article |
In situ mapping identifies distinct vascular niches for myelopoiesis
A combination of fluorescent antibodies is used to build visual maps of all myeloid cells in the bone marrow, providing new insight into how the bone marrow microenvironment regulates cell-fate decisions.
- Jizhou Zhang
- , Qingqing Wu
- & Daniel Lucas
-
Article |
Deciphering human macrophage development at single-cell resolution
Single-cell RNA sequencing of haematopoietic cells from human embryos at different developmental stages sheds light on the development and specification of macrophages in different tissues.
- Zhilei Bian
- , Yandong Gong
- & Bing Liu
-
Article |
Mouse models of neutropenia reveal progenitor-stage-specific defects
Mouse models of severe congenital neutropenia using patient-derived mutations in the GFI1 locus are used to determine the mechanisms by which the disease progresses.
- David E. Muench
- , Andre Olsson
- & H. Leighton Grimes
-
Letter |
Developmental origin, functional maintenance and genetic rescue of osteoclasts
Multinucleated osteoclasts required for normal bone development and tooth eruption in the mouse originate from embryonic erythro-myeloid progenitors and are maintained after birth by fusion with circulating monocytes.
- Christian E. Jacome-Galarza
- , Gulce I. Percin
- & Frederic Geissmann
-
Letter |
Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host
Microbial signals are crucial to the development of pre-leukaemic myeloproliferation, which can be induced by disrupting the intestinal barrier or by introducing systemic bacterial stimuli in Tet2-deficient mice.
- Marlies Meisel
- , Reinhard Hinterleitner
- & Bana Jabri
-
Letter |
A somatic mutation in erythro-myeloid progenitors causes neurodegenerative disease
Braf V600E expression in resident macrophage progenitors leads to clonal expansion of ERK-activated microglia, which causes synaptic and neuronal loss in the brain and results in lethal neurodegenerative disease in adult mice.
- Elvira Mass
- , Christian E. Jacome-Galarza
- & Frederic Geissmann
-
Letter |
Fetal liver endothelium regulates the seeding of tissue-resident macrophages
PLVAP selectively controls the seeding of fetal liver monocyte-derived tissue-resident macrophages, seemingly by interacting with chemotactic and adhesive molecules at the diaphragms of liver sinusoidal endothelium.
- Pia Rantakari
- , Norma Jäppinen
- & Marko Salmi
-
Letter |
Single-cell analysis of mixed-lineage states leading to a binary cell fate choice
Stem cells generate progenitors that transition through a series of dynamically unstable states with mixed-lineage gene expression, culminating in the specification of cell-fate.
- Andre Olsson
- , Meenakshi Venkatasubramanian
- & H. Leighton Grimes
-
Letter |
Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors
To determine the origin of adult tissue-resident macrophages, a mouse lineage tracing study has revealed that these cells derive from erythro-myeloid progenitors in the yolk sac that are distinct from fetal and adult haematopoietic stem cells.
- Elisa Gomez Perdiguero
- , Kay Klapproth
- & Hans-Reimer Rodewald
-
Article |
Clonal dynamics of native haematopoiesis
On the basis of transplantation experiments it is generally believed that a very small number of haematopoietic stem cells maintain multi-lineage haematopoiesis by stably producing a hierarchy of short-lived progenitor cells; here a new transposon-based labelling technique shows that this might not be the case during non-transplant haematopoiesis, but rather that a large number of long-lived progenitors are the main drivers of steady-state haematopoiesis during most of adulthood.
- Jianlong Sun
- , Azucena Ramos
- & Fernando D. Camargo
-
Letter |
Diverse and heritable lineage imprinting of early haematopoietic progenitors
In vivo ‘cellular barcoding’ shows that early haematopoietic progenitors are heterogeneous in the cell types that they produce, and this is partly due to an ‘imprinting’ of fate in progenitors, including for a separate dendritic cell lineage.
- Shalin H. Naik
- , Leïla Perié
- & Ton N. Schumacher
Nuclear morphology is shaped by loop-extrusion programs