Featured
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Structure of the shutdown state of myosin-2
The structure of myosin-2 in the shutdown state reveals how the shutdown state is stabilized and how phosphorylation of light chains allows myosin to be activated.
- Charlotte A. Scarff
- , Glenn Carrington
- & Michelle Peckham
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Cryo-EM structure of the inhibited (10S) form of myosin II
High-resolution cryo-electron microscopy structure of smooth muscle myosin II in the inhibited state enables increased understanding of the functions of the head and tail regions in regulation of myosin activity and the pathological mechanisms of disease mutations.
- Shixin Yang
- , Prince Tiwari
- & Roger Craig
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Genetic induction and mechanochemical propagation of a morphogenetic wave
Tissue shape changes in the posterior endoderm of the early Drosophila embryo are driven by actomyosin contractions emerging from a transcriptional induction followed by a mechanically-driven propagation of RhoI–myosin II activation.
- Anaïs Bailles
- , Claudio Collinet
- & Thomas Lecuit
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Letter |
Asymmetric division of contractile domains couples cell positioning and fate specification
Here, a combination of biophysical measurement, modelling, and genetic and experimental manipulation of cell contractile components is used to analyse the formation of the inner cell mass in the early mouse embryo.
- Jean-Léon Maître
- , Hervé Turlier
- & Takashi Hiiragi
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Letter |
Cryo-EM structure of a human cytoplasmic actomyosin complex at near-atomic resolution
The first high-resolution structure of a human actomyosin complex reveals the interface between F-actin and myosin in near-atomic detail.
- Julian von der Ecken
- , Sarah M. Heissler
- & Stefan Raunser
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Letter |
A self-organized biomechanical network drives shape changes during tissue morphogenesis
Feedbacks between the dissociation and advection of myosin II result in self-organized behaviour of actomyosin networks that drives shape changes during tissue morphogenesis.
- Akankshi Munjal
- , Jean-Marc Philippe
- & Thomas Lecuit
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Letter |
Apico-basal forces exerted by apoptotic cells drive epithelium folding
Apoptotic cell death is required for morphogenesis of the developing leg joint of fruitflies; using this model system, the authors show here that within apoptotic cells a transient pulling force exerted through a highly dynamic apico-basal myosin II cable-like structure acts as a mechanical signal to increase tissue tension and modify tissue shape.
- Bruno Monier
- , Melanie Gettings
- & Magali Suzanne
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Letter |
Non-muscle myosin IIA is a functional entry receptor for herpes simplex virus-1
Entry of herpes simplex virus-1 into cells requires cellular receptors for both envelope glycoprotein B and envelope glycoprotein D. These authors show that the interaction of non-muscle myosin heavy chain IIA with envelope glycoprotein B is important for entry of herpes simplex virus-1.
- Jun Arii
- , Hideo Goto
- & Yasushi Kawaguchi
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Article |
Video imaging of walking myosin V by high-speed atomic force microscopy
High-speed atomic force microscopy can be used to record the structure and dynamics of biomolecules simultaneously. These authors use this method to directly observe the dynamics of the motor protein myosin V moving along actin filaments, with unprecedented time resolution. The high-resolution movies provide evidence supporting the 'swinging lever-arm' model of myosin motility, and provide important insights into the mechanism of motor movement.
- Noriyuki Kodera
- , Daisuke Yamamoto
- & Toshio Ando
Cryo-EM structure of the human cardiac myosin filament
Myosin in motion