Nanomedicine articles within Nature Materials

Featured

  • Article |

    Gold nanoclusters show promise as photothermal materials, but are often thermally unstable. Here ligand engineering is used to integrate molecular rotors with gold nanoclusters to dissipate thermal energy and improve photothermal therapy performance.

    • Jing Chen
    • , Peilin Gu
    •  & Chunhai Fan

  • Article |

    Nanoparticle retention inside tumours has been associated with lymphatic vessel collapse. It is now shown that nanoparticles exit from solid tumours through lymphatic vessels in or surrounding the tumour by a nanoparticle-size-dependent mechanism.

    • Luan N. M. Nguyen
    • , Zachary P. Lin
    •  & Warren C. W. Chan

  • Review Article |

    RNA-based therapeutics hold promise for the treatment of several diseases. This Review provides an overview of hydrogels for RNA delivery, discussing how the chemical nature and physical properties of hydrogels can be explored for tailored RNA loading and release, and highlighting the use of these materials in biomedical applications.

    • Ruibo Zhong
    • , Sepehr Talebian
    •  & Jinjun Shi

  • News & Views |

    A polymeric nanoparticle adjuvant containing a Toll-like receptor 7 agonist elicits broad protection against viral challenges.

    • Jorge Huete-Carrasco
    •  & Ed C. Lavelle

  • Editorial |

    Materials scientists have played a key role in the global response to the COVID-19 pandemic from the development of vaccines and diagnostic tools to the rapid prototyping of ventilators.

  • News & Views |

    A nanosensor probe that combines a tumour-targeting peptide, a diagnostic reporter and an imaging contrast agent enables early diagnosis, precision imaging, disease stratification and downstream therapeutic response monitoring of metastatic cancer.

    • Matthew Bogyo

  • Perspective |

    This Perspective discusses biological barriers that have limited clinical translation of cancer nanomedicines and elaborates on new directions for the field that capitalize on a deeper understanding of the nano–bio interface.

    • Irene de Lázaro
    •  & David J. Mooney

  • News & Views |

    New evidence now suggests that the dominant mechanism of extravasation of nanoparticles into solid tumours may be through an active process of endothelial transcytosis.

    • Irene de Lázaro
    •  & David J. Mooney

  • Article |

    The dominant mechanism of nanoparticle entry into solid tumours has now been shown to be an active trans-endothelial pathway rather than the currently established passive transport via inter-endothelial gaps.

    • Shrey Sindhwani
    • , Abdullah Muhammad Syed
    •  & Warren C. W. Chan

  • News & Views |

    In a murine model of acute colitis, hyaluronic acid–bilirubin-based nanomaterials have been shown to modulate immune response and the gut microbiome, as well as restore the epithelial barrier.

    • Ankur Singh

  • Article |

    An anticancer agent, olsalazine, conjugated to a cell-penetrating peptide has been synthesized and shows the ability to self-assemble intracellularly by the tumour-associated enzyme furin, with the potential for tumour therapy and chemical exchange saturation transfer magnetic resonance imaging in vivo.

    • Yue Yuan
    • , Jia Zhang
    •  & Jeff W. M. Bulte

  • News & Views |

    An injectable biomaterial with angiogenic and immune-modulatory properties was developed and shown to support brain tissue repair and functional recovery in a mouse model of stroke.

    • Anup Tuladhar
    •  & Molly S. Shoichet

  • Article |

    The blood clearance mechanism, by the liver, of administered hard nanomaterials is reported in relation to blood flow dynamics, organ microarchitecture and cellular phenotype.

    • Kim M. Tsoi
    • , Sonya A. MacParland
    •  & Warren C. W. Chan

  • Review Article |

    This Review discusses the properties and applications of supramolecular biomaterials for drug delivery, tissue engineering, regenerative medicine and immunology.

    • Matthew J. Webber
    • , Eric A. Appel
    •  & Robert Langer

  • Editorial |

    Materials-based imaging agents are attractive candidates for a diverse range of imaging modalities and combined imaging–therapy applications, but economic implications and practical concerns remain obstacles to their clinical translation.

  • News & Views |

    Detection of a wide range of tumours remains a challenge in cancer diagnostics. By exploiting changes in the tumour microenvironment, a pH-responsive polymeric nanomaterial enables ultrasensitive tumour-specific imaging in many types of cancer.

    • Daishun Ling
    • , Michael J. Hackett
    •  & Taeghwan Hyeon

  • Commentary |

    Nanoparticle-based imaging plays a crucial role in cancer diagnosis and treatment. Here, we discuss the modalities used for molecular imaging of the tumour microenvironment and image-guided interventions including drug delivery, surgery and ablation therapy.

    • Chun Li

  • Article |

    The imaging of tumours is challenging because of the wide range of different cancers. Now, the rapid detection of tumours, independent of type, is achieved using a nonlinear amplification strategy that employs ultrasensitive pH-responsive fluorescent nanoparticles that illuminate within tumour neovasculature or in response to the tumour’s acidic extracellular environment.

    • Yiguang Wang
    • , Kejin Zhou
    •  & Jinming Gao

  • Commentary |

    Cancer nanomedicines approved so far minimize toxicity, but their efficacy is often limited by physiological barriers posed by the tumour microenvironment. Here, we discuss how these barriers can be overcome through innovative nanomedicine design and through creative manipulation of the tumour microenvironment.

    • Vikash P. Chauhan
    •  & Rakesh K. Jain

  • Commentary |

    Many materials-based therapeutic systems have reached the clinic or are in clinical trials. Here we describe materials design principles and the construction of delivery vehicles, as well as their adaptation and evaluation for human use.

    • Jeffrey A. Hubbell
    •  & Robert Langer

  • News & Views |

    A magnetic on/off switch for cell-death signalling in cancer cells is developed using antibodies conjugated to magnetic nanoparticles. The control of cell death in in vivo systems is demonstrated by a tell-tale morphological change within the zebrafish.

    • Jon Dobson

  • News & Views |

    A system comprising 'signalling' and 'receiving' modules — where the receiving module circulating in the bloodstream is directed to the tumour by a cascade triggered by the signalling module — improves the targeting effect of a nanomedicine.

    • Yucai Wang
    • , Paige Brown
    •  & Younan Xia

  • Article |

    A two-component nanoparticle system that communicates and enhances in vivo drug delivery and diagnostics has been devised. The system comprises ‘signalling’ nanoparticles that target tumours and then broadcast the tumour’s location to ’receiving’ nanoparticles in circulation, which carry therapeutic or diagnostic cargos, hence amplifying tumour targeting.

    • Geoffrey von Maltzahn
    • , Ji-Ho Park
    •  & Sangeeta N. Bhatia

Browse broader subjects

Browse narrower subjects

Browse Nanomedicine across other nature.com journals