Networks and systems biology articles within Nature

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• Article | 20 December 2023

  Discovery of a structural class of antibiotics with explainable deep learning

  An explainable deep learning model using a chemical substructure-based approach for the exploration of chemical compound libraries identified structural classes of compounds with antibiotic activity and low toxicity.

  • Felix Wong
  • , Erica J. Zheng
  •  & James J. Collins

• Article | 13 October 2021

  Systems-level effects of allosteric perturbations to a model molecular switch

  Interface mutations in the GTPase switch protein Gsp1 (the yeast homologue of human RAN) allosterically affect the kinetics of the switch cycle, revealing a systems-level mechanism of multi-specificity.

  • Tina Perica
  • , Christopher J. P. Mathy
  •  & Tanja Kortemme

• Brief Communications Arising | 19 October 2011

  Liu et al. reply

  • Yang-Yu Liu
  • , Jean-Jacques Slotine
  •  & Albert-László Barabási