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Ptbp1 deletion does not induce astrocyte-to-neuron conversion
- Thanh Hoang
- , Dong Won Kim
- & Seth Blackshaw
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Article |
Androgens increase excitatory neurogenic potential in human brain organoids
Experiments in cerebral organoids show that sex hormones have a role in regulating the number of excitatory neurons in the human neocortex, providing insight into the mechanistic basis of sex-related brain differences in humans.
- Iva Kelava
- , Ilaria Chiaradia
- & Madeline A. Lancaster
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Article
| Open Access
An atlas of cortical arealization identifies dynamic molecular signatures
RNA-sequencing analysis of the prenatal human brain at different stages of development shows that areal transcriptional signatures are dynamic and coexist with developmental and cell-type signatures.
- Aparna Bhaduri
- , Carmen Sandoval-Espinosa
- & Arnold R. Kriegstein
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Article |
Single-cell analysis reveals T cell infiltration in old neurogenic niches
Single-cell transcriptomic analysis of neurogenic niches in young and old mice reveals that T cells infiltrate the neurogenic niches of old mice and inhibit the proliferation of neural stem cells, in part through expression of interferon-γ.
- Ben W. Dulken
- , Matthew T. Buckley
- & Anne Brunet
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Letter |
The centrosome protein AKNA regulates neurogenesis via microtubule organization
The interphase centrosome protein AKNA is necessary and sufficient for the organization of centrosomal microtubules, mediates delamination in the formation of the subventricular zone and regulates exit from this zone.
- Germán Camargo Ortega
- , Sven Falk
- & Magdalena Götz
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Letter |
Onset of differentiation is post-transcriptionally controlled in adult neural stem cells
Sequencing of total and ribosome-associated mRNAs enables identification of specific mRNAs that are differentially translationally regulated along the neuronal stem cell lineage, independently of their availability.
- Avni Baser
- , Maxim Skabkin
- & Ana Martin-Villalba
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Letter |
Aspm knockout ferret reveals an evolutionary mechanism governing cerebral cortical size
In a ferret model, the microcephaly-associated gene Aspm regulates cortical expansion by controlling the transition of ventricular radial glial cells to more differentiated cell types.
- Matthew B. Johnson
- , Xingshen Sun
- & Byoung-Il Bae
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Article |
Assembly of functionally integrated human forebrain spheroids
Human pluripotent stem cells were used to develop dorsal and ventral forebrain 3D spheroids, which can be assembled to study interneuron migration and to derive a functionally integrated forebrain system with cortical interneurons and glutamatergic neurons.
- Fikri Birey
- , Jimena Andersen
- & Sergiu P. Paşca
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Article |
Integration of temporal and spatial patterning generates neural diversity
Combinatorial inputs from temporal and spatial axes act together to promote medullary neural diversity in the optic lobes of Drosophila.
- Ted Erclik
- , Xin Li
- & Claude Desplan
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Article |
Temporal patterning of Drosophila medulla neuroblasts controls neural fates
Five transcription factors are sequentially expressed in a temporal cascade in Drosophila medulla neuroblasts of the visual system; cross-regulations between these transcription factors control the temporal transitions, and temporal switching of neural progenitors may be a common theme in neuronal specification, with different sequences of transcription factors being used in different contexts.
- Xin Li
- , Ted Erclik
- & Claude Desplan
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Letter |
Protective astrogenesis from the SVZ niche after injury is controlled by Notch modulator Thbs4
This paper identifies a specific population of subventricular-zone-generated astrocytes that increases in population density after cortical injury; these activated astrocytes migrate to the site of injury, unlike described properties for their counterparts residing in the cortex.
- Eric J. Benner
- , Dominic Luciano
- & Chay T. Kuo
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Letter |
Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis
Adult neural stem and progenitor cells (NSPCs) show high levels of fatty acid synthase (Fasn)-dependent de novo lipogenesis, a process that is controlled by Spot14 to regulate the rate of proliferation; this indicates a functional coupling between the regulation of lipid metabolism and adult NSPC proliferation.
- Marlen Knobloch
- , Simon M. G. Braun
- & Sebastian Jessberger
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Research Highlights |
Stem cells wrap neurons
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Letter |
Progressive degeneration of human neural stem cells caused by pathogenic LRRK2
Investigation of neural cells from post-mortem human brains and differentiated from patient-derived induced pluripotent stem cells shows that the LRRK2 mutation (G2019S) associated with familial and sporadic Parkinson's disease correlates with abnormalities at the nuclear envelope.
- Guang-Hui Liu
- , Jing Qu
- & Juan Carlos Izpisua Belmonte
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Letter |
Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision
Parvalbumin-expressing interneurons regulate the activation and fate choice of adult neural stem cells.
- Juan Song
- , Chun Zhong
- & Hongjun Song
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Letter |
Ars2 maintains neural stem-cell identity through direct transcriptional activation of Sox2
Mammalian zinc finger protein Ars2 is revealed as a sequence-specific transcription factor that promotes the self-renewal of postnatal and adult neural stem cells by directly activating transcription of the pluripotency factor Sox2.
- Celia Andreu-Agullo
- , Thomas Maurin
- & Eric C. Lai
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Letter |
Corridors of migrating neurons in the human brain and their decline during infancy
- Nader Sanai
- , Thuhien Nguyen
- & Arturo Alvarez-Buylla
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Letter |
Postnatal loss of Dlk1 imprinting in stem cells and niche astrocytes regulates neurogenesis
- Sacri R. Ferrón
- , Marika Charalambous
- & Anne C. Ferguson-Smith
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Letter |
Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation
- Amar Sahay
- , Kimberly N. Scobie
- & René Hen
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Research Highlights |
Brain fluid spurs stem cells
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Letter |
Fat cells reactivate quiescent neuroblasts via TOR and glial insulin relays in Drosophila
Little is known about how nutritional cues are detected by quiescent neural stem cells (neuroblasts in Drosophila melanogaster) and how these signals are relayed to reactivate their cell cycle to exit quiescence. This study uses an integrative physiology approach to identify the relay mechanism regulating this nutritional checkpoint in neural progenitors. It is found that specific insulin-like peptides produced within the brain by glia bridge the amino-acid/TOR-dependent signal derived from the fat body with PI3K/TOR signalling in neuroblasts to induce exit from quiescent.
- Rita Sousa-Nunes
- , Lih Ling Yee
- & Alex P. Gould
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Letter |
Notch and EGFR pathway interaction regulates neural stem cell number and self-renewal
In the adult brain, neural stem cells (NSCs) and neural progenitor cells (NPCs) are maintained in the subventricular zone. There, the Notch protein regulates the identity and self-renewal of NSCs, while epidermal growth factor receptor (EGFR) affects NPC proliferation and migration. Now it is found that these signalling pathways interact to maintain the balance between NSC and NPC populations.
- Adan Aguirre
- , Maria E. Rubio
- & Vittorio Gallo
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Research Highlights |
Neuroimaging: Stem cells on screen
An epigenetic barrier sets the timing of human neuronal maturation