Neurogenesis articles within Nature

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  • Article |

    Challenging the belief that sympathetic ganglia are an innovation of jawed vertebrates, a study reports the presence of sympathetic neurons in an extant jawless vertebrate, the sea lamprey Petromyzon marinus.

    • Brittany M. Edens
    • , Jan Stundl
    •  & Marianne E. Bronner

  • Article
    | Open Access

    A proteomics analysis demonstrates that, during nutrient stress, mammalian cells prioritize degradation by autophagy of membrane proteins and identifies receptors that mediate this process at the Golgi and also have a role in Golgi remodelling during neuronal differentiation.

    • Kelsey L. Hickey
    • , Sharan Swarup
    •  & J. Wade Harper

  • Article |

    A technique to detect the release of N-terminal fragments of Drosophila adhesion G-protein-coupled receptors (aGPCRs) provides insight into the dissociation of aGPCRs, and shows that receptor autoproteolysis enables non-cell-autonomous activity of aGPCRs in the brain.

    • Nicole Scholz
    • , Anne-Kristin Dahse
    •  & Tobias Langenhan

  • Article
    | Open Access

    A multi-omic atlas of brain organoid development facilitates the inference of an underlying gene regulatory network using the newly developed Pando framework and shows—in conjunction with perturbation experiments—that GLI3 controls forebrain fate establishment through interaction with HES4/5 regulomes.

    • Jonas Simon Fleck
    • , Sophie Martina Johanna Jansen
    •  & Barbara Treutlein

  • Article
    | Open Access

    Evolutionary modelling shows that an initial set of inhibitory neurons serving olfactory bulbs may have been repurposed to diversify the taxonomy of interneurons found in the expanded striata and cortices in primates.

    • Matthew T. Schmitz
    • , Kadellyn Sandoval
    •  & Alex A. Pollen

  • Article |

    Haploinsufficiency in three genes associated with risk of autism spectrum disorder—KMT5B, ARID1B and CHD8—in cell lines from multiple donors results in cell-type-specific asynchronous development of GABAergic neurons and cortical deep-layer excitatory projection neurons.

    • Bruna Paulsen
    • , Silvia Velasco
    •  & Paola Arlotta

  • Article |

    Experiments in cerebral organoids show that sex hormones have a role in regulating the number of excitatory neurons in the human neocortex, providing insight into the mechanistic basis of sex-related brain differences in humans.

    • Iva Kelava
    • , Ilaria Chiaradia
    •  & Madeline A. Lancaster

  • Article |

    A chromatin accessibility atlas of 240,919 cells in the adult and developing Drosophila brain reveals 95,000 enhancers, which are integrated in cell-type specific enhancer gene regulatory networks and decoded into combinations of functional transcription factor binding sites using deep learning.

    • Jasper Janssens
    • , Sara Aibar
    •  & Stein Aerts

  • Article
    | Open Access

    RNA-sequencing analysis of the prenatal human brain at different stages of development shows that areal transcriptional signatures are dynamic and coexist with developmental and cell-type signatures.

    • Aparna Bhaduri
    • , Carmen Sandoval-Espinosa
    •  & Arnold R. Kriegstein

  • Article |

    A comprehensive single-cell transcriptomic atlas of the mouse brain between gastrulation and birth identifies hundreds of cellular states and reveals the spatiotemporal organization of brain development.

    • Gioele La Manno
    • , Kimberly Siletti
    •  & Sten Linnarsson

  • Article |

    The duration of a critical period of plasticity in the developing Drosophila motor circuit, during which motor neurons display activity-dependent refinement of neurite structure and connectivity, is dependent on astrocyte to motor neuron Neuroligin–Neurexin signalling.

    • Sarah D. Ackerman
    • , Nelson A. Perez-Catalan
    •  & Chris Q. Doe

  • Article |

    MicroRNAs from head and neck cancer cells, shuttled to sensory neurons by extracellular vesicles, cause a shift to an adrenergic neuronal phenotype that promotes tumour progression.

    • Moran Amit
    • , Hideaki Takahashi
    •  & Jeffrey N. Myers

  • Article |

    Single-cell RNA sequencing is used to catalogue and explore the developmental trajectories of more than 30,000 cells in the developing human hippocampus.

    • Suijuan Zhong
    • , Wenyu Ding
    •  & Xiaoqun Wang

  • Article |

    Single-cell transcriptomic analysis of neurogenic niches in young and old mice reveals that T cells infiltrate the neurogenic niches of old mice and inhibit the proliferation of neural stem cells, in part through expression of interferon-γ.

    • Ben W. Dulken
    • , Matthew T. Buckley
    •  & Anne Brunet

  • Article |

    In bilaterian animals, the final configurations of central nervous systems seem unrelated to neuroectodermal patterning systems, so it is likely that the various architectures of the ventral nerve cords evolved convergently, many times.

    • José M. Martín-Durán
    • , Kevin Pang
    •  & Andreas Hejnol

  • Article |

    One of the most abundant modifications found in messenger RNAs is N6-methyladenosine (m6A); here, this modification is shown to alter gene expression during sex determination and affect neuronal functions and behaviour in Drosophila via the m6A reader protein YT521-B.

    • Tina Lence
    • , Junaid Akhtar
    •  & Jean-Yves Roignant

  • Letter |

    Live imaging and single-cell analyses are used to show that decision-making by differentiating haematopoietic stem cells between the megakaryocytic–erythroid and granulocytic–monocytic lineages is not initiated by stochastic switching between the lineage-specific transcription factors PU.1 and GATA1, which challenges the previous model of early myeloid lineage choice.

    • Philipp S. Hoppe
    • , Michael Schwarzfischer
    •  & Timm Schroeder

  • Letter |

    Butterflies diversify their retinal mosaics by producing three stochastic types of ommatidia instead of the two types found in Drosophila; this study shows that butterfly retinas use two R7-like photoreceptors per ommatidium that each make an independent stochastic decision to express the transcription factor Spineless, which controls photoreceptor and ommatidial fate.

    • Michael Perry
    • , Michiyo Kinoshita
    •  & Claude Desplan

  • Letter |

    Neuronal precursor cells in the tunicate Ciona intestinalis are shown to delaminate and undergo directed cell migration along either side of the neural tube before differentiating into bipolar neurons, suggesting that vertebrate neural-crest-derived sensory neurons have much deeper evolutionary roots.

    • Alberto Stolfi
    • , Kerrianne Ryan
    •  & Lionel Christiaen

  • Article |

    Here the authors present a human pluripotent stem cell-derived three-dimensional organoid culture system that is able to recapitulate several aspects of human brain development in addition to modelling the brain disorder microcephaly, which has been difficult to achieve using mouse models.

    • Madeline A. Lancaster
    • , Magdalena Renner
    •  & Juergen A. Knoblich

  • Article |

    Five transcription factors are sequentially expressed in a temporal cascade in Drosophila medulla neuroblasts of the visual system; cross-regulations between these transcription factors control the temporal transitions, and temporal switching of neural progenitors may be a common theme in neuronal specification, with different sequences of transcription factors being used in different contexts.

    • Xin Li
    • , Ted Erclik
    •  & Claude Desplan

  • Letter |

    Adult neural stem and progenitor cells (NSPCs) show high levels of fatty acid synthase (Fasn)-dependent de novo lipogenesis, a process that is controlled by Spot14 to regulate the rate of proliferation; this indicates a functional coupling between the regulation of lipid metabolism and adult NSPC proliferation.

    • Marlen Knobloch
    • , Simon M. G. Braun
    •  & Sebastian Jessberger

  • Letter
    | Open Access

    A premature stop codon in the DMRT3 gene has a major effect on the pattern of locomotion in horses, and the Dmrt3 transcription factor is critical in the development of a coordinated locomotor network in mice, suggesting that it has an important role in configuring the spinal circuits that control stride.

    • Lisa S. Andersson
    • , Martin Larhammar
    •  & Klas Kullander

  • News & Views |

    The expression level of a single gene can determine head size in zebrafish, mirroring a human anatomical feature associated with neurological disorders such as autism and schizophrenia. See Letter p.363

    • Dheeraj Malhotra
    •  & Jonathan Sebat

  • News & Views |

    Unlike in other mammals, neuron production in the subventricular region of the human brain becomes depleted in early infancy. This finding calls for a reassessment of the potential role of adult neurogenesis in health and disease. See Letter p.382

    • Jon I. Arellano
    •  & Pasko Rakic

  • News |

    Results of marker studies monitoring developing brain cells should be interpreted with caution.

    • Mo Costandi

  • News & Views |

    The brain's ability to generate new neurons declines with age. This reduction is mediated by increased levels of an inflammatory factor in the blood of ageing mice and is associated with deficits in learning and memory. See Letter p.90

    • Richard M. Ransohoff

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