Neuroimmunology articles within Nature

Featured

  • Article |

    In an experimental autoimmune encephalomyelitis model in mice, a subset of astrocytes retains an epigenetically regulated memory of past inflammation, causing exacerbated inflammation upon subsequent rechallenge.

    • Hong-Gyun Lee
    • , Joseph M. Rone
    •  & Francisco J. Quintana

  • Article |

    Arachnoid cuff exit points create openings in the arachnoid barrier enabling the drainage of cerebrospinal fluid and exchange of molecules and cells between the dura and the subarachnoid space, therefore physically connecting the brain and the dura.

    • Leon C. D. Smyth
    • , Di Xu
    •  & Jonathan Kipnis

  • Article
    | Open Access

    Autoreactive T cells that target myelin antigens in the peripheral nerves are present in patients with the demyelinating form of Guillain–Barré syndrome, and these T cells are likely to contribute to disease pathophysiology.

    • L. Súkeníková
    • , A. Mallone
    •  & D. Latorre

  • Article
    | Open Access

    Platelet factors transfer the benefits of young blood to the ageing brain in mice through CXCR3, which mediates the cellular, molecular and cognitive benefits of systemic PF4 on the aged brain.

    • Adam B. Schroer
    • , Patrick B. Ventura
    •  & Saul A. Villeda

  • Article |

    Lactate produced by dendritic cells (DCs) suppresses T-cell-mediated autoimmunity through a mechanism in which lactate activates HIF-1α–NDUFA4L2 signalling in DCs and thereby limits DC-mediated pro-inflammatory responses such as the development of encephalitogenic T cells.

    • Liliana M. Sanmarco
    • , Joseph M. Rone
    •  & Francisco J. Quintana

  • Article
    | Open Access

    Mast cells are shown to function as sensor cells linking antigen recognition in type 2 immunity to antigen-specific avoidance behaviour, preventing immune activation and inflammation.

    • Thomas Plum
    • , Rebecca Binzberger
    •  & Hans-Reimer Rodewald

  • Article |

    A genome-wide association study including 22,389 cases of multiple sclerosis finds an association with disease progression at the DYSF–ZNF638 and DNM3–PIGC loci and identifies a potential of higher educational attainment in slowing disease progression.

    • Adil Harroud
    • , Pernilla Stridh
    •  & Kári Stefánsson

  • Article |

    Resident macrophages of the muscularis externa refine the enteric nervous system (ENS) early in life by pruning synapses and phagocytosing enteric neurons, and later switch to a neuro-supportive function, indicating that the ENS is governed by a dedicated population of resident macrophages that adapt to the timely needs of the ENS.

    • Maria Francesca Viola
    • , Marta Chavero-Pieres
    •  & Guy Boeckxstaens

  • Article
    | Open Access

    A small population of prostaglandin E2-responsive glossopharyngeal sensory neurons provides a sensory pathway between airway and brainstem that mediates sickness responses to early-phase influenza virus infection.

    • Na-Ryum Bin
    • , Sara L. Prescott
    •  & Stephen D. Liberles

  • Article |

    The pathogenic function of XBP1-expressing astrocytes in experimental autoimmune encephalomyelitis and multiple sclerosis have been studied using FIND-seq, a new method combining microfluidics cytometry, PCR-based detection of nucleic acids and cell sorting for in-depth single-cell transcriptomics analyses of rare cells.

    • Iain C. Clark
    • , Michael A. Wheeler
    •  & Adam R. Abate

  • Review Article |

    Anatomical, cellular and molecular immune interactions at the borders of the central nervous system control homeostatic brain function and can lead to neurological or psychiatric diseases, representing potential therapeutic targets.

    • Justin Rustenhoven
    •  & Jonathan Kipnis

  • Article |

    Perivascular and leptomeningeal macrophages, collectively termed here parenchymal border macrophages, are shown to regulate flow dynamics of cerebrospinal fluid, implicating this cell population as new therapeutic targets in neurological diseases such as Alzheimer’s.

    • Antoine Drieu
    • , Siling Du
    •  & Jonathan Kipnis

  • Article
    | Open Access

    Melanoma cells interact with pain-mediating sensory neurons by increasing their release of the neuropeptide CGRP, which increases the exhaustion of CD8+ T cells and thus promotes the survival of cancer cells.

    • Mohammad Balood
    • , Maryam Ahmadi
    •  & Sebastien Talbot

  • Article
    | Open Access

    A studying using a set of unbiased methodologies shows that a specific subpopulation of neurons in the brainstem can regulate the diverse responses to a bacterial endotoxin that induces sickness behaviours.

    • Anoj Ilanges
    • , Rani Shiao
    •  & Jeffrey M. Friedman

  • Article |

    An immune signature characterized by activated antigen-specific CD8 T cells is identified in the brain and blood of mice with amyotrophic lateral sclerosis-4 (ALS4), suggesting that the immune system is involved in ALS4 neurodegeneration.

    • Laura Campisi
    • , Shahab Chizari
    •  & Ivan Marazzi

  • Article |

    Single-cell profiling and fate-mapping experiments in the developing brain of mice and humans show that microglia and meningeal macrophages originate from a common prenatal precursor, but that perivascular macrophages are derived postnatally from meningeal macrophages.

    • Takahiro Masuda
    • , Lukas Amann
    •  & Marco Prinz

  • Article |

    Work in experimental autoimmune models shows that the lung microbiome is linked to immune reactivity in the brain through a mechanism in which the balance of pulmonary microorganisms regulates the activation state of microglia.

    • Leon Hosang
    • , Roger Cugota Canals
    •  & Francesca Odoardi

  • Article |

    A subset of inflammatory group 3 innate lymphoid cells, here termed iILC3s, infiltrate the central nervous system and promote neuroinflammation and disease progression in a mouse model of multiple sclerosis.

    • John B. Grigg
    • , Arthi Shanmugavadivu
    •  & Gregory F. Sonnenberg

  • Article |

    Single-nucleus transcriptomes of frontal cortex and choroid plexus samples from patients with COVID-19 reveal pathological cell states that are similar to those associated with human neurodegenerative diseases and chronic brain disorders.

    • Andrew C. Yang
    • , Fabian Kern
    •  & Tony Wyss-Coray

  • Article |

    Specialized somatosensory neurons that express Gαi-interacting protein (GINIP) promote tissue repair in a model of UV-induced skin damage by secreting the neuropeptide TAFA4, which regulates skin-resident macrophages to release IL-10 and limit fibrosis.

    • Guillaume Hoeffel
    • , Guilhaume Debroas
    •  & Sophie Ugolini

  • Article |

    In aged mice, inhibition of prostaglandin E2 (PGE2) signalling through its receptor EP2 improves cellular bioenergetics, reduces inflammatory responses and restores hippocampal plasticity to youthful levels, resulting in an improvement in spatial memory and cognition.

    • Paras S. Minhas
    • , Amira Latif-Hernandez
    •  & Katrin I. Andreasson

  • Article |

    A subpopulation of astrocytes characterized by the expression of LAMP1 and TRAIL limits inflammation in the central nervous system through a mechanism involving the microbiota-modulated expression of IFNγ in meningeal natural killer cells.

    • Liliana M. Sanmarco
    • , Michael A. Wheeler
    •  & Francisco J. Quintana

  • Article |

    Studies of mice and humans suggest a role for loss of the C9orf72 protein in some neurodegenerative disorders: with reduced C9orf72 levels, there is more inflammation mediated by the STING protein in immune and brain cells.

    • Madelyn E. McCauley
    • , Jacqueline Gire O’Rourke
    •  & Robert H. Baloh

  • Article |

    A combination of gnotobiotic mouse models, transcriptomics, circuit tracing and chemogenetic manipulations identifies neuronal circuits that integrate microbial signals in the gut with regulation of the sympathetic nervous system.

    • Paul A. Muller
    • , Marc Schneeberger
    •  & Daniel Mucida

  • Article |

    A liver–brain–gut neural circuit responds to the gut microenvironment and regulates the activity of peripheral regulatory T cells in the colon by controlling intestinal antigen-presenting cells in a muscarinic signalling-dependent manner.

    • Toshiaki Teratani
    • , Yohei Mikami
    •  & Takanori Kanai

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