Nucleolus articles within Nature

Featured

• Article | 15 July 2020

  Nucleolar RNA polymerase II drives ribosome biogenesis

  RNA polymerase II has an unexpected function in the nucleolus, helping to drive the expression of ribosomal RNA and to protect nucleolar structure through a mechanism involving triplex R-loop structures.

  • Karan J. Abraham
  • , Negin Khosraviani
  •  & Karim Mekhail

• Article | 06 May 2020

  Composition-dependent thermodynamics of intracellular phase separation

  Heterotypic multicomponent interactions are shown to dominate the liquid–liquid phase separation that enables the formation of intracellular condensates.

  • Joshua A. Riback
  • , Lian Zhu
  •  & Clifford P. Brangwynne

• Article | 05 March 2014

  C9orf72 nucleotide repeat structures initiate molecular cascades of disease

  Structurally polymorphic C9orf72 hexanucleotide repeats cause an impairment in transcriptional processivity and lead to accumulation of truncated repeat-containing transcripts that bind to specific ribonucleoproteins, such as nucleolin, in a conformation-dependent manner resulting in nucleolar stress and C9orf72-linked pathology in amyotrophic lateral sclerosis and frontotemporal dementia.

  • Aaron R. Haeusler
  • , Christopher J. Donnelly
  •  & Jiou Wang

• Research Highlights | 31 March 2010

  Genomics: DNA packaging unravelled