Oligodendrocyte articles within Nature

Featured

  • Letter |

    Single-nucleus RNA sequencing analysis identifies different subclusters of oligodendroglia in white matter from individuals with multiple sclerosis compared with controls, and these differences may be important for understanding disease progression.

    • Sarah Jäkel
    • , Eneritz Agirre
    •  & Gonçalo Castelo-Branco

  • Letter |

    There are no new oligodendrocytes in potentially remyelinated multiple sclerosis shadow plaques, although oligodendrocyte generation is increased in the normal appearing white matter of patients with aggressive disease, informing the development of new therapies.

    • Maggie S. Y. Yeung
    • , Mehdi Djelloul
    •  & Jonas Frisén

  • Letter |

    Ischaemia damages nerve myelin by depriving neurons and their myelinating oligodendrocytes of oxygen and glucose; here it is shown that ischaemic damage is caused through the H+-dependent activation of TRPA1 channels, and not via glutamate receptors of the NMDA type, as previously thought, providing a new mechanism and promising therapeutic targets for diseases as diverse and prevalent as cerebral palsy, spinal cord injury, stroke and multiple sclerosis.

    • Nicola B. Hamilton
    • , Karolina Kolodziejczyk
    •  & David Attwell

  • Letter |

    Diffuse white matter injury is common in very preterm infants; here, enhanced epidermal growth factor receptor signalling in oligodendrocyte precursor cells in a mouse model of such injury is shown to increase cellular and functional recovery.

    • Joseph Scafidi
    • , Timothy R. Hammond
    •  & Vittorio Gallo

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